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Suppressive control of optokinetic and vestibular nystagmus by the primate frontal eye field.
Journal of Neurophysiology ( IF 2.5 ) Pub Date : 2020-07-29 , DOI: 10.1152/jn.00015.2020
Yoshiko Izawa 1 , Hisao Suzuki 1
Affiliation  

When the eyes are fixated on a spot, fixation neurons in the frontal eye field (FEF) show an increase in activity. Our previous study suggested that fixation neurons in the FEF contribute to the suppression of saccades and smooth pursuit eye movements to maintain active fixation. The present study examined the role of the FEF in the suppressive control of reflexive eye movements, optokinetic and vestibular nystagmus, in trained monkeys. Electrical stimulation in the FEF suppressed the quick and slow phases of optokinetic and vestibular nystagmus at an intensity lower than the threshold for eliciting electrically evoked saccades. Relatively weak suppression influenced the slow phase of vestibular nystagmus. During optokinetic or vestibular nystagmus, presentation of a stationary small spot to the eyes followed by fixation is known to suppress both the quick and slow phases of eye movements. We recorded the activity of fixation neurons in the FEF and found that fixation neurons usually showed a decrease in activity during optokinetic and vestibular nystagmus and an increase in activity during the suppression of nystagmus by visual fixation. The present results show that the activity of fixation neurons in the FEF is related to the suppressive control of optokinetic and vestibular nystagmus for maintaining active fixation. We discuss the role of a generalized visual fixation system that can maintain visual attention on an interesting object.

中文翻译:

灵长类额叶眼场对视动和前庭眼球震颤的抑制控制。

当眼睛注视一个点时,额叶眼场 (FEF) 中的注视神经元活动增加。我们之前的研究表明,FEF 中的注视神经元有助于抑制扫视和平滑追踪眼球运动,以保持主动注视。本研究检查了 FEF 在受过训练的猴子的反射性眼球运动、视动和前庭眼球震颤的抑制控制中的作用。FEF 中的电刺激以低于引发电诱发眼跳的阈值的强度抑制了视动和前庭眼球震颤的快速和慢速阶段。相对较弱的抑制影响了前庭性眼球震颤的慢相。在视动或前庭眼球震颤期间,众所周知,向眼睛呈现一个静止的小点,然后进行注视,可以抑制眼球运动的快速和慢速阶段。我们记录了 FEF 中固视神经元的活动,发现固视神经元通常在视动和前庭眼球震颤期间活动减少,而在通过视觉固定抑制眼球震颤期间活动增加。目前的结果表明,FEF 中固视神经元的活动与维持主动固视的视动和前庭眼球震颤的抑制控制有关。我们讨论了可以保持对有趣物体的视觉注意力的广义视觉固定系统的作用。我们记录了 FEF 中固视神经元的活动,发现固视神经元通常在视动和前庭眼球震颤期间活动减少,而在通过视觉固定抑制眼球震颤期间活动增加。目前的结果表明,FEF 中固视神经元的活动与维持主动固视的视动和前庭眼球震颤的抑制控制有关。我们讨论了可以保持对有趣物体的视觉注意力的广义视觉固定系统的作用。我们记录了 FEF 中固视神经元的活动,发现固视神经元通常在视动和前庭眼球震颤期间活动减少,而在通过视觉固定抑制眼球震颤期间活动增加。目前的结果表明,FEF 中固视神经元的活动与维持主动固视的视动和前庭眼球震颤的抑制控制有关。我们讨论了可以保持对有趣物体的视觉注意力的广义视觉固定系统的作用。目前的结果表明,FEF 中固视神经元的活动与维持主动固视的视动和前庭眼球震颤的抑制控制有关。我们讨论了可以保持对有趣物体的视觉注意力的广义视觉固定系统的作用。目前的结果表明,FEF 中固视神经元的活动与维持主动固视的视动和前庭眼球震颤的抑制控制有关。我们讨论了可以保持对有趣物体的视觉注意力的广义视觉固定系统的作用。
更新日期:2020-08-20
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