Abstract Background Multisystem Inflammatory Syndrome in Children (MIS-C) related to coronavirus disease-2019 (COVID-19) is an emergent syndrome affecting children globally in the wake of the SARS-CoV-2 pandemic. The clinical presentation has similarities to Kawasaki disease and toxic shock syndrome. As knowledge of the cardiac and gastrointestinal manifestations has been emerging, little is known about the impact on the brain. Method This case describes a 14-year-old boy who developed prominent neuropsychiatric symptoms including delirium followed by impairments in executive functioning in the context of MIS-C with positive SARS-CoV-2 antibodies. These symptoms improved in correlation with improvements in inflammatory markers. Results Neuropsychiatric manifestations including confusion, irritability, and headaches have been reported in pediatric patients with MIS-C. Potential mechanisms include direct neurotropic effect of SARS-CoV-2, secondary effects of systemic inflammation, and/or adverse side effects of treatment. Conclusions MIS-C is a novel and poorly understood syndrome related to SARS-CoV-2 with effects on multiple organ systems including the central nervous system. As additional cases are reported and research expands, so too will our understanding of the neuropsychiatric manifestations. Better understanding of the underlying pathophysiology would aid in determining targeted interventions.

中文翻译：

---

患有儿童多系统炎症综合征 (MIS-C) 的青春期男孩的神经精神症状

摘要 背景 与 2019 年冠状病毒病 (COVID-19) 相关的儿童多系统炎症综合征 (MIS-C) 是 SARS-CoV-2 大流行后影响全球儿童的一种新出现的综合征。临床表现与川崎病和中毒性休克综合征相似。随着对心脏和胃肠道表现的了解不断涌现，人们对它对大脑的影响知之甚少。方法 该病例描述了一名 14 岁男孩，在 SARS-CoV-2 抗体阳性的 MIS-C 背景下，出现了明显的神经精神症状，包括谵妄，随后出现执行功能障碍。这些症状的改善与炎症标志物的改善相关。结果 MIS-C 儿科患者出现神经精神症状，包括精神错乱、烦躁和头痛。潜在机制包括 SARS-CoV-2 的直接神经营养作用、全身炎症的继发作用和/或治疗的不良副作用。结论 MIS-C 是一种与 SARS-CoV-2 相关的新型且知之甚少的综合征，对包括中枢神经系统在内的多个器官系统有影响。随着更多病例的报道和研究的扩大，我们对神经精神表现的理解也会随之加深。更好地了解潜在的病理生理学将有助于确定有针对性的干预措施。