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Branching out: what omics can tell us about primate evolution.
Current Opinion in Genetics & Development ( IF 4 ) Pub Date : 2020-07-04 , DOI: 10.1016/j.gde.2020.06.006
Lukas Fk Kuderna 1 , Paula Esteller-Cucala 1 , Tomas Marques-Bonet 2
Affiliation  

The study of primate comparative genomics has long been a focus of research, particularly in the context of understanding human evolutionary history. Recently, high-throughput methods have become accessible that allow us to tackle these questions at scale by comparing genomes within and between species, or looking at gene regulatory and expression changes between species and tissues. This burst in large-scale genomic studies has drastically increased the resolution at which we are now able to understand the evolutionary forces acting upon our own species. Furthermore, the drop in sequencing costs has made it possible to go beyond generating datasets that focus purely on human biology, and to begin incorporating larger genomic studies of non-human primates. Here, we give an overview of recent advances in large-scale high-throughput studies across the whole primate radiation.

中文翻译:

扩展:组学可以告诉我们有关灵长类动物进化的信息。

灵长类动物比较基因组学的研究长期以来一直是研究的重点,特别是在理解人类进化历史的背景下。最近,高通量方法已经变得可用,使我们能够通过比较物种内和物种之间的基因组,或观察物种和组织之间的基因调控和表达变化来大规模解决这些问题。大规模基因组研究的爆发大大提高了我们现在能够理解作用于我们自己物种的进化力量的分辨率。此外,测序成本的下降使生成仅关注人类生物学的数据集成为可能,并开始纳入对非人类灵长类动物的更大规模基因组研究。这里,
更新日期:2020-07-04
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