Background: An eco-friendly, operationally simple and efficient reaction is shown between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic acid.

Methods: The reaction between various 2,6-bis-(substituted-benzylidene)-cyclohexanones and differently substituted hydrazine in the presence of acetic acid afforded 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7- hexahydro-2H-indazole in 74 to 92 % yield in short reaction time using the grindstone technique.

Results and Discussion: The notable advantages of this method include mild synthetic conditions, weak acid catalysis, and non-hazardous solvent which make this method environmentally safer.

Conclusion: In conclusion, we have developed an efficient, simple and eco-friendly method for the synthesis of 7-Benzylidene-substituted-phenyl-3,3a,4,5,6,7-hexahydro-2H-indazole by grinding technique. The notable benefits of this method are waste minimization, no organic solvent required, simple procedure, easy work-up, and clean reaction profile.

背景：在乙酸的存在下，各种2，6-双-（取代的亚苄基）-环己酮与不同取代的肼之间发生了环保，操作简单且有效的反应。

方法：在乙酸存在下，各种2,6-双-（取代亚苄基）-环己酮与不同取代的肼反应，得到7-亚苄基取代的苯基-3,3a，4,5,6,7-使用砂轮技术，六氢-2H-吲唑的反应时间短，产率为74％至92％。

结果与讨论：该方法的显着优势包括温和的合成条件，弱酸催化作用和无害溶剂，这使该方法对环境更加安全。

结论：总之，我们已经开发了一种高效，简单且环保的方法，通过研磨技术合成7-亚苄基取代的苯基-3,3a，4,5,6,7-六氢-2H-吲唑。该方法的显着优势是废物最少，不需要有机溶剂，操作简单，后处理容易并且反应曲线干净。