当前位置: X-MOL 学术Antimicrob. Agents Chemother. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Prevalence and Antimicrobial Susceptibility of Mycoplasma hominis and Ureaplasma Species in Nonpregnant Female Patients in South Korea Indicate an Increasing Trend of Pristinamycin-Resistant Isolates.
Antimicrobial Agents and Chemotherapy ( IF 4.9 ) Pub Date : 2020-09-21 , DOI: 10.1128/aac.01065-20
Ji Yong Lee 1 , Jeong Seon Yang 2
Affiliation  

Mycoplasma hominis and Ureaplasma species, commonly found in the lower urogenital tract, have been associated with various urogenital infections. This study aimed to estimate the prevalence and antimicrobial susceptibility trend of M. hominis and Ureaplasma sp. in female patients and to evaluate the risk factors for the acquisition of pristinamycin-resistant mycoplasma. Endocervical swab specimens obtained between March 2016 and December 2018 were analyzed using a Mycoplasma IST2 kit. Because pristinamycin and josamycin are not available in South Korea, we conducted an age- and date-matched case-control study to evaluate the risk factors for the acquisition of pristinamycin-resistant isolates. Among 4,035 specimens, 1,589 (39.4%) cases were positive for genital mycoplasma, which included 49 (3.1%) cases of M. hominis, 1,243 (78.2%) cases of Ureaplasma sp., and 297 (18.7%) cases of both M. hominis and Ureaplasma species. Based on antimicrobial susceptibility tests, the antibiotic susceptible rate of both M. hominis and Ureaplasma species to pristinamycin decreased annually during the study period (100%, 97.1%, and 87.3% for 2016, 2017, and 2018, respectively, P < 0.001). According to a multivariate analysis, josamycin resistance (odds ratio, 7.18; 95% confidence interval, 1.20 to 43.00; P = 0.027) and coinfection (odds ratio, 145.38; 95% confidence interval, 21.80 to 3,017.23; P < 0.001) with Candida species were independent risk factors for the acquisition of pristinamycin-resistant isolates. Antibiotic-resistant genital mycoplasmas have been gradually increasing annually. Nationwide surveillance, proper antibiotic stewardship, and appropriate culture-based treatment strategies are required to control this upcoming threat.

中文翻译:

在韩国未怀孕的女性患者中,人型支原体和脲原体的患病率和药敏性表明耐普瑞霉素的分离株呈上升趋势。

常见于泌尿生殖道下段的人支原体脲原体物种与各种泌尿生殖道感染有关。这项研究旨在估计人型支原体脲原体的患病率和耐药性趋势sp。在女性患者中进行评估,并评估获得耐普瑞霉素的支原体的危险因素。使用支原体IST2试剂盒分析了2016年3月至2018年12月之间获得的宫颈拭子标本。由于在韩国没有Pristinamycin和Josamycin,我们进行了年龄和日期匹配的病例对照研究,以评估获得耐Pristinamycin分离株的风险因素。间4035周的标本,1589(39.4%)例阳性生殖器支原体,其中包括49(3.1%)的箱子人型支原体,1243(78.2%)的情况下,解脲属,297(18.7%)两者的情况下,中号人型脲原体种类。根据抗菌药敏试验,研究期间人型分枝杆菌和脲原体对抗生素的敏感率逐年下降(2016年,2017年和2018年分别为100%,97.1%和87.3%,P <0.001) 。根据本发明的多变量分析,交沙霉素抗性(比值比,7.18; 95%置信区间,1.20至43.00; P = 0.027)和共感染(比值比,145.38; 95%置信区间,21.80到3,017.23; P <0.001)与念珠菌菌种是获得抗普瑞霉素菌株的独立危险因素。耐药性生殖道支原体每年都在逐渐增加。为了控制这种即将到来的威胁,需要在全国范围内进行监视,采取适当的抗生素管理以及适当的基于文化的治疗策略。
更新日期:2020-09-21
down
wechat
bug