Applied Physiology, Nutrition, and Metabolism, Ahead of Print.
Whey protein comprises soluble whey proteins and its benefits are well described in the literature. However, there are not many studies investigating the potential adverse effect of a diet with indiscriminate use of this supplement. The aim of this study was to perform a systematic review of papers that addressed this theme. A search was conducted in Medline, LILACS, TOXNET, Web of science, and Scopus electronic databases. In the end, 11 documents comprised this review. The majority of the papers associated the damaging effect with the chronic and abusive use of whey protein, with the kidneys and liver being the main organs affected. The other studies related whey protein to aggravation of aggression, presence of acne, and modification of the microbiota. Therefore, excessive consumption over a long period of protein supplementation may have some adverse effects on the body, which is aggravated when associated with sedentary lifestyle. PROSPERO registration no.: CRD42020140466. Novelty: A systematic review of experimental and randomized studies about the use of whey proteins supplements and its impact on physical health. Analysis revealed that chronic and without professional guidance use of whey protein supplementation may cause some adverse effects specially on kidney and liver function. Presented data support a need for future studies co-relating the use of different types of whey protein with and without exercise to better see the impact on human physical health.

中文翻译：

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乳清蛋白补充剂及其对健康的潜在不利影响：系统评价。

应用生理学、营养学和代谢，提前出版。
乳清蛋白包括可溶性乳清蛋白，其益处在文献中有详细描述。然而，没有多少研究调查不加区别地使用这种补充剂的饮食的潜在不利影响。本研究的目的是对涉及该主题的论文进行系统审查。在 Medline、LILACS、TOXNET、Web of science 和 Scopus 电子数据库中进行了搜索。最终，11 份文件构成了本次审查。大多数论文将破坏性影响与长期和滥用乳清蛋白联系起来，肾脏和肝脏是受影响的主要器官。其他研究将乳清蛋白与攻击性加重、痤疮的存在和微生物群的改变相关联。所以，长期过量食用补充蛋白质可能对身体产生一些不利影响，如果与久坐不动的生活方式相关联，则这种影响会加剧。PROSPERO 注册号：CRD42020140466。新颖性：关于乳清蛋白补充剂的使用及其对身体健康影响的实验和随机研究的系统评价。分析表明，长期在没有专业指导的情况下使用乳清蛋白补充剂可能会对肾脏和肝脏功能产生一些不良影响。提供的数据支持未来研究的需要，将不同类型乳清蛋白的使用与运动和不运动相关联，以更好地了解对人体健康的影响。关于乳清蛋白补充剂的使用及其对身体健康影响的实验和随机研究的系统评价。分析表明，长期在没有专业指导的情况下使用乳清蛋白补充剂可能会对肾脏和肝脏功能产生一些不良影响。提供的数据支持未来研究的需要，将不同类型乳清蛋白的使用与运动和不运动相关联，以更好地了解对人体健康的影响。关于乳清蛋白补充剂的使用及其对身体健康影响的实验和随机研究的系统评价。分析表明，长期在没有专业指导的情况下使用乳清蛋白补充剂可能会对肾脏和肝脏功能产生一些不良影响。提供的数据支持未来研究的需要，将不同类型乳清蛋白的使用与运动和不运动相关联，以更好地了解对人体健康的影响。