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Future Directions for Infant Identification and Intervention for Autism Spectrum Disorder from a Transdiagnostic Perspective.
Journal of Clinical Child & Adolescent Psychology ( IF 5.077 ) Pub Date : 2020-07-23 , DOI: 10.1080/15374416.2020.1790382
Meagan R Talbott 1 , Meghan R Miller 1
Affiliation  

By the time they are typically detected, neurodevelopmental disorders like autism spectrum disorder (ASD) are already challenging to treat. Preventive and early intervention strategies in infancy are critical for improving outcomes over the lifespan with significant cost savings. However, the impact of prevention and early intervention efforts is dependent upon our ability to identify infants most appropriate for such interventions. Because there may be significant overlap between prodromal symptoms across neurodevelopmental disorders and child psychopathology more broadly which may wax and wane across development, we contend that the impact of prevention and early intervention efforts will be heightened by identifying early indicators that may overlap across ASD and other commonly co-occurring disorders. This paper summarizes the existing literature on infant symptoms and identification of ASD to demonstrate the ways in which a transdiagnostic perspective could expand the impact of early identification and intervention research and clinical efforts, and to outline suggestions for future empirical research programs addressing current gaps in the identification-to-treatment pipeline. We propose four recommendations for future research that are both grounded in developmental and clinical science and that are scalable for early intervention systems: (1) development of fine-grained, norm-referenced measures of ASD-relevant transdiagnostic behavioral domains; (2) identification of shared and distinct mechanisms influencing the transition from risk to disorder; (3) determination of key cross-cutting treatment strategies (both novel and extracted from existing approaches) effective in targeting specific domains across disorders; and (4) integration of identified measures and treatments into existing service systems.



中文翻译:

从跨诊断角度看自闭症谱系障碍婴儿识别和干预的未来方向。

当他们通常被检测到时,像自闭症谱系障碍 (ASD) 这样的神经发育障碍已经很难治疗了。婴儿期的预防和早期干预策略对于改善整个生命周期的结果并节省大量成本至关重要。然而,预防和早期干预工作的影响取决于我们识别最适合此类干预的婴儿的能力。由于神经发育障碍的前驱症状与更广泛的儿童精神病理学之间可能存在显着重叠,这可能在整个发育过程中起伏不定,我们认为,通过确定可能在 ASD 和其他疾病中重叠的早期指标,预防和早期干预工作的影响将得到加强常见的并发疾病。本文总结了有关婴儿症状和 ASD 识别的现有文献,以展示跨诊断观点如何扩大早期识别和干预研究及临床工作的影响,并为未来的实证研究计划提出建议,以解决目前在 ASD 方面的差距识别到治疗管道。我们为未来的研究提出了四项建议,这些建议都基于发展和临床科学,并且可扩展到早期干预系统:(1)开发与 ASD 相关的跨诊断行为领域的细粒度、规范参考措施;(2) 确定影响从风险到混乱转变的共有和不同的机制;(3) 确定有效针对跨障碍特定领域的关键交叉治疗策略(包括新颖的和从现有方法中提取的);(4) 将确定的措施和处理方法整合到现有的服务系统中。

更新日期:2020-07-23
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