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Autophagy in immunity.
Progress in Molecular Biology and Translational Science ( IF 4.025 ) Pub Date : 2020-03-28 , DOI: 10.1016/bs.pmbts.2020.03.005
Christian Münz 1
Affiliation  

The molecular machinery of macroautophagy consists of Atg proteins and supports cytoplasmic constituent degradation in lysosomes as its canonical function, phagosome maturation and exocytosis. These different biological processes contribute to cell intrinsic, innate and adaptive immunity. For the respective immune responses, Atg proteins mediate direct pathogen degradation, inflammation restriction, antigen presentation on MHC molecules and survival of memory lymphocyte populations. During adaptive immunity MHC class II presentation of antigens is supported and MHC class I presentation restricted by the macroautophagy machinery. Considering these various functions might allow us to predict the outcome of interventions that manipulate the machinery of Atg proteins as immunotherapies for the benefit of human health.



中文翻译:

自噬免疫力。

巨自噬的分子机制由Atg蛋白组成,并支持溶酶体中的胞质成分降解,因为它具有典型的功能,吞噬体成熟和胞吐作用。这些不同的生物学过程有助于细胞固有的,固有的和适应性免疫。对于各自的免疫应答,Atg蛋白介导直接的病原体降解,炎症限制,MHC分子上的抗原呈递和记忆淋巴细胞群的存活。在适应性免疫过程中,支持MHC II类抗原呈递,而MHC I类呈递受宏观自噬机制限制。考虑到这些不同的功能,可能使我们能够预测以Atg蛋白为免疫机制的干预手段的干预效果,从而使人类健康受益。

更新日期:2020-03-28
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