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Protrudin in protrudinG invadopodia: Membrane contact sites and cell invasion
The Journal of Cell Biology Pub Date : 2020-07-21 , DOI: 10.1083/jcb.202006146 Amita Arora 1, 2 , Vesa M Olkkonen 1, 2
The Journal of Cell Biology Pub Date : 2020-07-21 , DOI: 10.1083/jcb.202006146 Amita Arora 1, 2 , Vesa M Olkkonen 1, 2
Affiliation
Invadopodia are dynamic protrusions that harbor matrix metalloproteinases for pericellular matrix degradation. However, the mechanisms underlying their maturation are poorly understood. Pedersen et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202003063) demonstrate a dual role of Protrudin in invadopodia elongation and matrix degradation, central to cell invasion and cancer metastasis.
中文翻译:
突出侵袭伪足中的 Protrudin:膜接触位点和细胞侵袭
侵袭伪足是动态突起,含有用于细胞周基质降解的基质金属蛋白酶。然而,人们对它们成熟的机制知之甚少。佩德森等人。(2020. J. Cell Biol.https://doi.org/10.1083/jcb.202003063) 证明了 Protrudin 在侵袭伪足伸长和基质降解中的双重作用,这是细胞侵袭和癌症转移的核心。
更新日期:2020-07-21
中文翻译:
突出侵袭伪足中的 Protrudin:膜接触位点和细胞侵袭
侵袭伪足是动态突起,含有用于细胞周基质降解的基质金属蛋白酶。然而,人们对它们成熟的机制知之甚少。佩德森等人。(2020. J. Cell Biol.https://doi.org/10.1083/jcb.202003063) 证明了 Protrudin 在侵袭伪足伸长和基质降解中的双重作用,这是细胞侵袭和癌症转移的核心。