Multiplexing techniques, including the Hadamard transform, are widely used in the recovery of weak signals from high-level noise. Hadamard transform ion mobility spectrometry (HT-IMS), however, can suffer serious drawbacks due to false peaks. False peaks in HT-IMS are generally attributed to nonperfect gating behavior. This paper confirmed that the origin of false peaks in HT-IMS is not generally due to ion gating but rather to peak shifts by Coulombic repulsion of the ion packets inside the drift tube. The amplitudes of these false peaks are determined by the number of ions inside the ion packets. This phenomenon is simulated and confirmed by the convolution of the spectrum with a shifted s-sequence to reproduce the artifact peaks with the exact position, amplitude, and profile. Two approaches, including preoffset sequence modulation and post-data processing, were evaluated to mitigate the false peaks in HT-IMS, and both methods can work effectively.

中文翻译：

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模拟，预测和最小化Hadamard变换离子迁移谱的假峰。

包括Hadamard变换在内的多路复用技术已广泛用于从高电平噪声中恢复微弱信号。但是，由于假峰，哈达玛变换离子迁移谱（HT-IMS）可能遭受严重的缺点。HT-IMS中的假峰通常归因于不完美的门控行为。本文证实了HT-IMS中错误峰的起源通常不是由于离子门控，而是由于漂移管内离子包的库仑排斥引起的峰移动。这些假峰的幅度由离子包内部的离子数确定。通过频谱与卷积s序列的卷积可以模拟并确认这种现象，以再现具有精确位置，幅度和轮廓的伪影峰。两种方法