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Investigating the Levels of Brain-Specific Proteins in Hydrocephalus Patients
Combinatorial Chemistry & High Throughput Screening ( IF 1.8 ) Pub Date : 2021-02-28 , DOI: 10.2174/1386207323666200720093245
Ahmet Guzelcicek 1 , Ataman Gönel 2 , Ismail Koyuncu 2 , Gulyara Cigdem 3 , Dogan Kose 1 , Mehmet Karadag 4 , Dursun Cadirci 5
Affiliation  

Background: Hydrocephalus, a common brain disorder in children, can cause permanent brain damage. A timely diagnosis of this disorder is crucial.

Objective: The aim of this study was to evaluate the levels of S-100, CK-18, and NSE brainspecific proteins in patients with hydrocephalus. We examined the levels of these proteins in the blood samples of hydrocephalic patients.

Methods: The study was conducted on the hydrocephalus (n = 31) patients and a healthy control group (n = 30). A Receiver Operating Characteristic (ROC) curve was used to assess the validity of the NSE, CK-18, and S100B to differentiate between the hydrocephalus and the control groups. The suitability of the data to the normal distribution was tested with the Shapiro Wilk test, and the Student t-test was used to compare the characteristics of the normal distribution in two independent groups. The individuals in the hydrocephalus and control groups had similar values in terms of age, height, and weight.

Results: It was observed that NSE, CK-18, and S100B mean values of the individuals in the hydrocephalus group were significantly higher than NSE, CK-18, and S100B mean values of the control group.

Conclusion: Experiments have shown that the levels of these proteins increase significantly in hydrocephalus patients compared to the healthy group. These three parameters can be considered as important markers in the diagnosis of hydrocephalus.



中文翻译:

调查脑积水患者脑特异性蛋白的水平

背景:脑积水是儿童常见的脑部疾病,可导致永久性脑损伤。及时诊断这种疾病至关重要。

目的:本研究的目的是评估脑积水患者中 S-100、CK-18 和 NSE 脑特异性蛋白的水平。我们检查了脑积水患者血液样本中这些蛋白质的水平。

方法:本研究对脑积水(n = 31)患者和健康对照组(n = 30)进行。接受者操作特征 (ROC) 曲线用于评估 NSE、CK-18 和 S100B 区分脑积水组和对照组的有效性。用Shapiro Wilk检验检验数据对正态分布的适用性,用Student t检验比较两个独立组的正态分布特征。脑积水组和对照组中的个体在年龄、身高和体重方面具有相似的值。

结果:观察到脑积水组个体的NSE、CK-18、S100B均值显着高于对照组的NSE、CK-18、S100B均值。

结论:实验表明,与健康组相比,脑积水患者的这些蛋白质水平显着增加。这三个参数可以被认为是诊断脑积水的重要标志物。

更新日期:2021-02-18
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