In this issue, Raso et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202002175) uncover a novel replication fork speed regulatory network controlled by the ubiquitin-like modifier interferon-stimulated gene 15 (ISG15), which plays a central role in the innate immune response and regulates tumorigenesis as well as chemotherapy response.

中文翻译：

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ISG15 快速追踪 DNA 复制

在本期中，Raso 等人。(2020. J. Cell Biol.https://doi.org/10.1083/jcb.202002175) 揭示了一种由泛素样修饰剂干扰素刺激基因 15 (ISG15) 控制的新型复制叉速度调节网络，该基因在在先天免疫反应中发挥作用并调节肿瘤发生以及化疗反应。