Subspecies Niche Specialization in the Oral Microbiome Is Associated with Nasopharyngeal Carcinoma Risk.,mSystems

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Subspecies Niche Specialization in the Oral Microbiome Is Associated with Nasopharyngeal Carcinoma Risk.
mSystems ( IF 6.4 ) Pub Date : 2020-07-07 , DOI: 10.1128/msystems.00065-20
Justine W Debelius ₁ , Tingting Huang _{1,

2} , Yonglin Cai _{3,

4} , Alexander Ploner ₁ , Donal Barrett ₁ , Xiaoying Zhou _{5,

6} , Xue Xiao ₇ , Yancheng Li _{3,

4} , Jian Liao ₈ , Yuming Zheng _{3,

4} , Guangwu Huang ₇ , Hans-Olov Adami _{1,

9} , Yi Zeng ₁₀ , Zhe Zhang ₇ , Weimin Ye ₁₁

Affiliation

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Department of Cancer Prevention Center, Wuzhou Red Cross Hospital, Wuzhou, People's Republic of China.
Wuzhou Health System Key Laboratory for Nasopharyngeal Carcinoma Etiology and Molecular Mechanism, Wuzhou, People's Republic of China.
Life Science Institute, Guangxi Medical University, Nanning, People's Republic of China.
Key Laboratory of High-Incidence-Tumor Prevention & Treatment (Guangxi Medical University), Ministry of Education, Nanning, People's Republic of China.
Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Cangwu Institute for Nasopharyngeal Carcinoma Control and Prevention, Wuzhou, People's Republic of China.
Clinical Effectiveness Research Group, Institute of Health, University of Oslo, Oslo, Norway.
State Key Laboratory for Infectious Diseases Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Oral health and changes in the oral microbiome have been associated with both local and systemic cancer. Poor oral hygiene is a known risk factor for nasopharyngeal carcinoma (NPC), a virally associated head and neck cancer endemic to southern China. We explored the relationship between NPC and the oral microbiome using 16S rRNA sequencing in a study of 499 NPC patients and 495 population-based age and sex frequency-matched controls from an area of endemicity of Southern China. We found a significant reduction in community richness in cases compared to that in controls. Differences in the overall microbial community structure between cases and controls could not be explained by other potential confounders; disease status explained 5 times more variation in the unweighted UniFrac distance than the next most explanatory variable. In feature-based analyses, we identified a pair of coexcluding Granulicatella adiacens amplicon sequence variants (ASVs) which were strongly associated with NPC status and differed by a single nucleotide. The G. adiacens variant an individual carried was also associated with the overall microbial community based on beta diversity. Co-occurrence analysis suggested the two G. adiacens ASVs sit at the center of two coexcluding clusters of closely related organisms. Our results suggest there are differences in the oral microbiomes between NPC patients and healthy controls, and these may be associated with both a loss of microbial diversity and niche specialization among closely related commensals.

更新日期：2020-08-20

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