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The impact of parenting a child with serious mental illness: Accounting for the parent's genetic vulnerability to mental illness.
Journal of Family Psychology ( IF 3.302 ) Pub Date : 2020-07-16 , DOI: 10.1037/fam0000783
Jan Greenberg 1 , Emily C Hilton 2 , James J Li 2 , Qiongshi Lu 3 , Marsha R Mailick 2
Affiliation  

Parents of adults with serious mental illness (SMI) often are primary caregivers for their affected relative. Prior work has suggested that the toll of caregiving is associated with poorer well-being in family caregivers, particularly parents of affected adults. However, due to methodological limitations, it has not been possible to assess these family caregivers' own genetic vulnerability to mental and physical health problems, and thus the impact of caregivers' genetic risk on well-being may not have been accounted for. With the addition of genetic data to large survey samples, family caregivers' genetic vulnerability to mental and physical health problems can now be estimated. Parents from the Wisconsin Longitudinal Study who have an adult child with an SMI (n = 265) and a comparison group of parents with a child without disabilities (n = 5,036) reported their psychological well-being and mental and physical health across 4 measures. Genetic vulnerability was assessed using polygenic risk scores of neuroticism, bipolar disorder, schizophrenia, and depression. Results indicate that the effect of having a child with an SMI still had significant effects for all 4 parental health outcomes even after controlling for these measures of genetic vulnerability. This study's results affirm the negative health impact of parenting a child with SMI, above and beyond genetic vulnerability. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

中文翻译:

养育患有严重精神疾病的孩子的影响:解释父母对精神疾病的遗传易感性。

患有严重精神疾病 (SMI) 的成年人的父母通常是其受影响亲属的主要照顾者。先前的研究表明,看护的代价与家庭看护者的幸福感较差有关,尤其是受影响成年人的父母。然而,由于方法上的限制,无法评估这些家庭照顾者自身对心理和身体健康问题的遗传脆弱性,因此可能没有考虑到照顾者的遗传风险对幸福感的影响。通过将遗传数据添加到大型调查样本中,现在可以估计家庭照顾者对心理和身体健康问题的遗传脆弱性。来自威斯康星州纵向研究的父母有 SMI 成年子女 (n = 265) 和有非残疾儿童的父母对照组 (n = 5,036) 报告了他们在 4 项测量中的心理健康和身心健康。使用神经质、双相情感障碍、精神分裂症和抑郁症的多基因风险评分评估遗传脆弱性。结果表明,即使在控制了这些遗传易感性措施后,生育 SMI 孩子的影响仍然对所有 4 项父母健康结果产生显着影响。这项研究的结果证实了养育患有 SMI 的孩子对健康的负面影响,超出了遗传脆弱性。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。036) 通过 4 项措施报告了他们的心理健康和身心健康。使用神经质、双相情感障碍、精神分裂症和抑郁症的多基因风险评分评估遗传脆弱性。结果表明,即使在控制了这些遗传易感性措施后,生育 SMI 孩子的影响仍然对所有 4 项父母健康结果产生显着影响。这项研究的结果证实了养育患有 SMI 的孩子对健康的负面影响,超出了遗传脆弱性。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。036) 通过 4 项措施报告了他们的心理健康和身心健康。使用神经质、双相情感障碍、精神分裂症和抑郁症的多基因风险评分评估遗传脆弱性。结果表明,即使在控制了这些遗传易感性措施后,生育 SMI 孩子的影响仍然对所有 4 项父母健康结果产生显着影响。这项研究的结果证实了养育患有 SMI 的孩子对健康的负面影响,超出了遗传脆弱性。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。结果表明,即使在控制了这些遗传易感性措施后,生育 SMI 孩子的影响仍然对所有 4 项父母健康结果产生显着影响。这项研究的结果证实了养育患有 SMI 的孩子对健康的负面影响,超出了遗传脆弱性。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。结果表明,即使在控制了这些遗传易感性措施后,生育 SMI 孩子的影响仍然对所有 4 项父母健康结果产生显着影响。这项研究的结果证实了养育患有 SMI 的孩子对健康的负面影响,超出了遗传脆弱性。(PsycInfo 数据库记录 (c) 2020 APA,保留所有权利)。
更新日期:2020-07-16
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