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Neonatal exposure to chlordecone alters female social behaviors and central estrogen alpha receptor expression in socially monogamous mandarin voles.
Toxicology Research ( IF 2.1 ) Pub Date : 2020-04-29 , DOI: 10.1093/toxres/tfaa014
Ting Lian 1, 2 , Xudong Zhang 3 , Xiye Wang 2 , Rong Wang 4 , Huan Gao 4 , Fadao Tai 5 , Qi Yu 1
Affiliation  

Chlordecone (CD) is one of the common persistent organic pollutants in nature and has a profound impact on the environment and on public health. Accumulating evidence has demonstrated that neonatal exposure of CD influences adult physiology and behavior due to its estrogenic properties. Using socially monogamous mandarin voles as an experimental animal model, the present study aimed to evaluate the impact of neonatal exposure to CD on female social behaviors and central estrogen receptor alpha (ERα) expression in adulthood. After receiving a single subcutaneous injection with sesame seed oil (female control group), 17 beta-estradiol (E2 group), or CD group on postnatal Day 1, the social behaviors of adult animals and ERα expression in specific brain regions were assessed. The data indicated that CD or E2-treated female animals displayed increased affiliative behaviors and decreased aggressive behaviors with regard to the unfamiliar females in the social interaction test. In addition, CD or E2-treated female voles exhibited significant preferences to females over males in the sexual preference test. Moreover, CD-treated female animals exhibited higher levels of ERα expression in the bed nucleus of the stria terminalis, the central amygdala, the medial amygdala and the medial preoptic area compared with those of the control voles. The results suggested that neonatal exposure to CD may masculinize female social behaviors, possibly via CD-induced changes in the ERα expression of relevant brain regions.

中文翻译:

新生儿接触十氯酮会改变社交一夫一妻制田鼠中的女性社交行为和中央雌激素α受体表达。

十氯酮(CD)是自然界中常见的持久性有机污染物之一,对环境和公众健康具有深远的影响。越来越多的证据表明,由于CD的雌激素特性,CD的新生儿暴露会影响成人的生理和行为。本研究使用社会上一夫一妻制的普通田鼠作为实验动物模型,旨在评估新生儿接触CD对成年女性社会行为和中央雌激素受体α(ERα)表达的影响。在出生后第1天接受皮下注射芝麻油(女性对照组),17β-雌二醇(E 2组)或CD组后,评估了成年动物的社交行为和特定大脑区域的ERα表达。数据表明CD或E在社交互动测试中,与不熟悉的雌性相比,用2处理的雌性动物表现出增加的联结行为和减弱的攻击行为。另外,在性偏好测试中,用CD或E 2处理的雌性田鼠对雌性比雄性表现出明显的偏好。此外,与对照田鼠相比,经CD处理的雌性动物在终末纹,中央杏仁核,杏仁核内侧和视前内侧区域的床核中表现出更高水平的ERα表达。结果表明,新生儿接触CD可能使女性的社交行为男性化,可能是CD诱导的相关大脑区域ERα表达的变化所致。
更新日期:2020-04-29
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