Objective

Considering the osteoarthritis (OA) model that integrates the biological, mechanical, and structural components of the disease, the present study aimed to investigate the association between urinary C-Telopeptide fragments of type II collagen (uCTX-II), knee joint moments, pain, and physical function in individuals with medial knee OA.

Methods

Twenty-five subjects radiographically diagnosed with knee OA were recruited. Participants were evaluated through three-dimensional gait analysis, uCTX-II level, the WOMAC pain and physical function scores, and the 40 m walk test. The association between these variables was investigated using Pearson's product-moment correlation, followed by a hierarchical linear regression, controlled by OA severity and body mass index (BMI).

Results

No relationship was found between uCTX-II level and knee moments. A significant correlation between uCTX-II level and pain, physical function, and the 40 m walk test was found. The hierarchical linear regression controlling for OA severity and BMI showed that uCTX-II level explained 9% of the WOMAC pain score, 27% of the WOMAC physical function score, and 7% of the 40 m walk test.

Conclusion

Greater uCTX-II level is associated with higher pain and reduced physical function and 40 m walk test performance in individuals with medial knee OA.

中文翻译：

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膝关节内侧骨关节炎患者II型胶原蛋白尿C-四肽片段与膝关节负荷，疼痛和身体机能之间的关系。

目的

考虑到整合了疾病的生物学，机械和结构成分的骨关节炎（OA）模型，本研究旨在研究II型胶原的尿C-四肽片段（uCTX-II），膝关节力矩，疼痛之间的关联和膝内侧骨关节炎患者的身体机能。

方法

招募了二十五个经放射学诊断为膝骨关节炎的受试者。通过三维步态分析，uCTX-II水平，WOMAC疼痛和身体功能评分以及40 m步行测试对参与者进行评估。使用Pearson乘积矩相关性研究了这些变量之间的关联，然后进行了线性线性回归，并由OA严重性和体重指数（BMI）控制。

结果

在uCTX-II水平和膝力矩之间未发现任何关系。发现uCTX-II水平与疼痛，身体功能和40 m步行测试之间存在显着相关性。控制OA严重程度和BMI的分层线性回归表明，uCTX-II水平解释了WOMAC疼痛评分的9％，WOMAC身体功能评分的27％和40 m步行测试的7％。

结论

较高的uCTX-II水平与膝内侧骨关节炎患者的较高疼痛和降低的身体机能以及40 m步行测试性能相关。