Here we present a simple and cost effective procedure to improve the spatial resolution of the commercial MALDI source of a LTQ Orbitrap. Based in spatial filtering techniques, we demonstrate that, with minimal modifications of the original set up, the system resolution can be pushed forward to <10 μm. The improved system performance is demonstrated by means of MALDI imaging of human colon biopsies.

中文翻译：

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改善LTQ Orbitrap MALDI源的空间分辨率。

在这里，我们提出了一种简单且具有成本效益的程序，以提高LTQ Orbitrap的商业MALDI源的空间分辨率。基于空间滤波技术，我们证明，只需对原始设置进行最少的修改，即可将系统分辨率提高到<10μm。通过对人结肠活检的MALDI成像证明了系统性能的提高。