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Microbes as Biosensors.
Annual Review of Microbiology ( IF 10.5 ) Pub Date : 2020-09-09 , DOI: 10.1146/annurev-micro-022620-081059
Maria Eugenia Inda 1, 2 , Timothy K Lu 1, 2, 3
Affiliation  

The ability to detect disease early and deliver precision therapy would be transformative for the treatment of human illnesses. To achieve these goals, biosensors that can pinpoint when and where diseases emerge are needed. Rapid advances in synthetic biology are enabling us to exploit the information-processing abilities of living cells to diagnose disease and then treat it in a controlled fashion. For example, living sensors could be designed to precisely sense disease biomarkers, such as by-products of inflammation, and to respond by delivering targeted therapeutics in situ. Here, we provide an overview of ongoing efforts in microbial biosensor design, highlight translational opportunities, and discuss challenges for enabling sense-and-respond precision medicines.

中文翻译:


微生物作为生物传感器。

及早发现疾病并提供精确治疗的能力将对人类疾病的治疗具有革命性意义。为了实现这些目标,需要可以查明何时何地出现疾病的生物传感器。合成生物学的飞速发展使我们能够利用活细胞的信息处理能力来诊断疾病,然后以可控的方式对其进行治疗。例如,可以将活体传感器设计为精确感测疾病生物标记物(例如炎症的副产品),并通过就地提供靶向治疗剂做出反应。在这里,我们概述了微生物生物传感器设计方面正在进行的工作,重点介绍了转化机会,并讨论了实现感官响应型精密药物的挑战。

更新日期:2020-09-10
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