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Computational RNA Epigenetics
Current Genomics ( IF 2.6 ) Pub Date : 2020-03-25 , DOI: 10.2174/138920292101200305145123
Wei Chen 1, 2, 3, 4, 5, 6, 7, 8
Affiliation  

Besides ncRNAs, RNA modification is another layer of epigenetic regulation of gene expression. Since the first modified RNA ribonucleic acid was found in 1957, more than 150 kinds of known RNA modifications have been reported. RNA modifications play critical roles in a series of biological processes, such as RNA degradation, localization and degradation, and even circadian rhythm. Recent studies revealed that RNA modifications are also associated with metabolic diseases, cancer, neurological disorders and cardiovascular diseases.

中文翻译:

计算 RNA 表观遗传学

除了 ncRNA,RNA 修饰是基因表达的另一层表观遗传调控。自 1957 年发现第一个修饰的 RNA 核糖核酸以来,已报道了 150 多种已知的 RNA 修饰。RNA 修饰在一系列生物过程中发挥着关键作用,例如 RNA 降解、定位和降解,甚至昼夜节律。最近的研究表明,RNA 修饰还与代谢疾病、癌症、神经系统疾病和心血管疾病有关。
更新日期:2020-03-25
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