The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation. Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted for in-depth exploring Cbl’s definite role during osteoclastogenesis, as well as its cross talking with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of Cbl, as well as its cross-talking in bone homeostasis.

已发现 E3 泛素连接酶 Cbl 在调节细胞增殖和迁移中起重要作用。而破骨细胞的过度分化和/或其吸收功能的过度表达可能通过过度骨基质降解导致病理性骨稳态。自从几十年前首次报道 Cbl 在调节破骨细胞分化（也称为破骨细胞生成）中的重要作用以来。已经进行了广泛的研究，以深入探索 Cbl 在破骨细胞生成过程中的明确作用，以及它在骨稳态中与其他信号通路（例如：Src 和 PI3K 信号通路）的交叉对话。进来吧，我们目前的研究旨在简要总结当前关于破骨细胞生成和 Cbl 调节作用的研究，