In the present study, ultrathin poly(L-lactic acid) (PLLA) films were fabricated using the spin-coating technique. Physicochemical properties of the formed materials, including their morphology, thickness, transparency, and contact angle, have been studied. We determined that the morphology of PLLA films could be regulated by changing the polymer concentration and humidity. By altering the humidity, microporous and flat PLLA films can be fabricated. The obtained samples were subsequently used for culturing mesenchymal stem cells and fibroblasts. It has been determined that cells effectively adhered to prepared films and formed on them a monolayer culture with high viability. It has been shown that PLLA films are suitable for the entrapment of curcumin (up to 12.1 μm cm⁻²) and provide its sustained release in solutions isotonic to blood plasma. The obtained PLLA films appear to be prospective materials for potential application in regenerative medicine as part of cell-containing tissue engineered dressings for chronic wound treatment.

在本研究中，使用旋涂技术制造了超薄聚 (L-乳酸) (PLLA) 薄膜。已经研究了形成的材料的物理化学性质，包括它们的形态、厚度、透明度和接触角。我们确定可以通过改变聚合物浓度和湿度来调节 PLLA 薄膜的形态。通过改变湿度，可以制造微孔和平坦的 PLLA 薄膜。所得样品随后用于培养间充质干细胞和成纤维细胞。已经确定细胞有效地粘附在制备的薄膜上并在其上形成具有高活力的单层培养物。已经表明，PLLA 薄膜适用于包裹姜黄素（高达 12.1 μm cm ^-2) 并在与血浆等渗的溶液中提供其持续释放。所获得的 PLLA 薄膜似乎是在再生医学中潜在应用的潜在材料，作为用于慢性伤口治疗的含细胞组织工程敷料的一部分。