Introduction. Periprosthetic joint infections caused by methicillin-resistant Staphylococcus aureus (MRSA-PJIs) are rare, with only a few studies reporting the treatment outcomes and even fewer reporting outcomes with one-stage exchange. Aim. This study aims to analyse the outcomes of one-stage exchange in the management of MRSA-PJIs. Methodology. Patients with MRSA-PJI of the hip and knee, who were treated with a one-stage exchange between 2001 and 2018 were enrolled in this study. The final cohort comprised of 29 patients, which included 23 hips and six knees. The mean follow-up was 5.3 years (1–9 years). Reinfection and complications rates after the one-stage exchange were analysed. Results. Overall infection control could be achieved in 93.1 % (27 out of 29 patients). The overall revision rate was 31.0% (9 patients), with three patients requiring an in-hospital revision (10.3 %). Six patients had to be revised after hospital discharge (20.7 %). Of the two reinfections, one had a growth of MRSA while the other was of methicillin-sensitive Staphyloccocus epidermidis. Conclusion. One-stage exchange surgery using current techniques could improve surgical outcomes with excellent results in the management of MRSA-PJIs.

中文翻译：

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改良的治疗策略可在MRSA假体周围关节感染的一阶段交换手术后带来更好的治疗效果。

介绍。由耐甲氧西林的金黄色葡萄球菌（MRSA-PJI）引起的假肢周围感染很少见，只有少数研究报告了治疗结果，而一阶段交换报告的结果更少。目的。本研究旨在分析MRSA-PJI管理中的一阶段交换结果。方法。这项研究纳入了2001年至2018年间接受一阶段交换治疗的髋部和膝盖MRSA-PJI患者。最后的队列包括29名患者，其中包括23髋和6膝。平均随访时间为5.3年（1–9年）。一阶段交换后的再感染和并发症发生率进行了分析。结果。 总体感染控制率达到93.1％（29名患者中的27名）。总体翻修率为31.0％（9例），其中3例需要住院翻修（10.3％）。出院后有6例患者被修改（20.7％）。在两种再感染中，一种感染了MRSA，而另一种感染了对甲氧西林敏感的表皮葡萄球菌。结论。使用当前技术进行的一阶段交换手术可以改善手术效果，并在MRSA-PJI的治疗中获得出色的效果。