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Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance.
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2020-10-06 , DOI: 10.1146/annurev-cellbio-100818-125346
Kirsty Logan 1 , George Du Toit 1 , Mattia Giovannini 1, 2 , Victor Turcanu 3 , Gideon Lack 1
Affiliation  

Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Infant weaning guidelines in the United Sates were recently amended to actively encourage the introduction of peanut for prevention of peanut allergy.

中文翻译:


小儿过敏性疾病、食物过敏和口腔耐受性。

小儿过敏性疾病是世界范围内重大的健康问题,儿童湿疹、哮喘、过敏性鼻炎和食物过敏的患病率持续增加。支持特定干预措施预防湿疹、哮喘和过敏性鼻炎的证据有限,并且尚未就预防策略达成共识。通过口服耐受诱导和早期引入过敏性食物来研究预防食物过敏的随机对照试验已经成功地降低了花生和鸡蛋过敏的流行率。美国最近修订了婴儿断奶指南,积极鼓励引入花生以预防花生过敏。

更新日期:2020-10-08
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