Evidence suggests that physical activity (PA) is positively associated with (health-related) quality of life (QOL) in colorectal cancer survivors. However, little is known regarding long-term effects of PA on QOL and if prediagnosis PA is associated with QOL in the years after diagnosis. Our study aimed to investigate the association of prediagnosis and postdiagnosis PA with long-term QOL in colorectal cancer survivors. This study is based on a population-based cohort from Germany of 1,781 newly diagnosed colorectal cancer survivors over a 5-year period. PA was assessed at diagnosis and at 5-year follow-up (5YFU). Quality of life was assessed by the European Organisation for Research and Treatment of Cancer C Quality of Life Questionnaire QLQ-C30 at 5YFU. Multivariable linear regression was used to explore associations between prediagnosis and postdiagnosis PA and QOL at 5YFU. No evidence of a positive association between higher levels of prediagnosis PA and better long-term QOL was found. Higher levels of prediagnosis work-related PA and vigorous PA were even associated with decreased QOL in domains such as cognitive [Beta(β) = −2.52, 95% confidence interval (CI) = −3.77, −1.27; β = −1.92, CI = −3.17, −0.67) and emotional functioning (β = −2.52, CI = −3.84, −1.19; β = −2.12, CI = −3.44, −0.80). In cross-sectional analyses, higher postdiagnosis PA was strongly associated with higher QOL. Survivors physically active at both prediagnosis and postdiagnosis as well as survivors who increased their PA between prediagnosis and postdiagnosis reported significantly higher long-term QOL compared with survivors who remained inactive at prediagnosis and postdiagnosis. In this study, higher prediagnosis PA does not appear to be associated with higher QOL among long-term colorectal cancer survivors but our results support the importance of ongoing PA throughout survivorship.

中文翻译：

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结直肠癌幸存者的体力活动和长期生活质量——一项基于人群的前瞻性研究

有证据表明，体育活动 (PA) 与结直肠癌幸存者的（健康相关）生活质量 (QOL) 呈正相关。然而，关于 PA 对 QOL 的长期影响以及诊断前 PA 是否与诊断后几年的 QOL 相关，我们知之甚少。我们的研究旨在调查结直肠癌幸存者的诊断前和诊断后 PA 与长期 QOL 的关联。该研究基于来自德国的 1,781 名新诊断的结直肠癌幸存者在 5 年内的人群队列。PA 在诊断和 5 年随访 (5YFU) 时进行评估。生活质量由欧洲癌症研究和治疗组织 C 生活质量问卷 QLQ-C30 在 5YFU 评估。多变量线性回归用于探索诊断前和诊断后 PA 和 5YFU 的 QOL 之间的关联。没有发现更高水平的诊断前 PA 与更好的长期 QOL 之间存在正相关的证据。较高水平的与诊断前工作相关的 PA 和剧烈的 PA 甚至与认知等领域的 QOL 降低有关 [Beta(β) = -2.52, 95% 置信区间 (CI) = -3.77, -1.27; β = -1.92, CI = -3.17, -0.67) 和情绪功能 (β = -2.52, CI = -3.84, -1.19; β = -2.12, CI = -3.44, -0.80)。在横断面分析中，较高的诊断后 PA 与较高的 QOL 密切相关。与在诊断前和诊断后保持不活动的幸存者相比，在诊断前和诊断后身体活动的幸存者以及在诊断前和诊断后之间增加 PA 的幸存者报告的长期 QOL 显着更高。在这项研究中，在长期结直肠癌幸存者中，较高的诊断前 PA 似乎与较高的 QOL 无关，但我们的结果支持在整个生存过程中持续 PA 的重要性。