Cancer treatments have improved significantly during the last decade but are not yet satisfactory. Combination therapy is often administered to improve efficacy and safety. Drug delivery systems can also improve efficacy and safety. To control the spatiotemporal distribution of drugs, nanotechnology involving liposomes, solid lipid nanoparticles, and polymeric micelles has been developed. Co-delivery systems of multiple drugs are a promising approach to combat cancer. Synergistic effects and reduced side effects are expected from the use of co-delivery systems. In this review, we summarize various co-delivery systems for multiple drugs, including small-molecule drugs, nucleic acids, genes, and proteins. Co-delivery of drugs with different properties is relatively difficult, but some researchers have succeeded in developing such co-delivery systems. Environment-responsive carrier designs can control the release of cargos. Although their preparation is more complicated than that of mono-delivery systems, co-delivery systems can simplify clinical procedures and improve patient QOL.

中文翻译：

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使用纳米技术的多种药物的共同递送系统，用于未来的癌症治疗。

在过去十年中，癌症治疗已有显着改善，但仍不令人满意。经常进行联合治疗以提高疗效和安全性。药物输送系统也可以提高功效和安全性。为了控制药物的时空分布，已经开发了涉及脂质体，固体脂质纳米颗粒和聚合物胶束的纳米技术。多种药物的共同给药系统是对抗癌症的一种有前途的方法。通过使用共同给药系统，有望产生协同作用并减少副作用。在这篇综述中，我们总结了多种药物的多种共同递送系统，包括小分子药物，核酸，基因和蛋白质。共同递送具有不同特性的药物相对困难，但是一些研究人员已成功开发了此类共同递送系统。对环境敏感的承运人设计可以控制货物的放行。尽管它们的制备比单药分娩系统更复杂，但共药分娩系统可以简化临床程序并改善患者的生活质量。