当前位置: X-MOL 学术Chem. Pharm. Bull. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Recent Strategies for Targeted Brain Drug Delivery.
Chemical & Pharmaceutical Bulletin ( IF 1.7 ) Pub Date : 2020-01-01 , DOI: 10.1248/cpb.c20-00041
Koki Ogawa 1 , Naoya Kato 1 , Shigeru Kawakami 1
Affiliation  

Because the brain is the most important human organ, many brain disorders can cause severe symptoms. For example, glioma, one type of brain tumor, is progressive and lethal, while neurodegenerative diseases cause severe disability. Nevertheless, medical treatment for brain diseases remains unsatisfactory, and therefore innovative therapies are desired. However, the development of therapies to treat some cerebral diseases is difficult because the blood-brain barrier (BBB) or blood-brain tumor barrier prevents drugs from entering the brain. Hence, drug delivery system (DDS) strategies are required to deliver therapeutic agents to the brain. Recently, brain-targeted DDS have been developed, which increases the quality of therapy for cerebral disorders. This review gives an overview of recent brain-targeting DDS strategies. First, it describes strategies to cross the BBB. This includes BBB-crossing ligand modification or temporal BBB permeabilization. Strategies to avoid the BBB using local administration are also summarized. Intrabrain drug distribution is a crucial factor that directly determines the therapeutic effect, and thus it is important to evaluate drug distribution using optimal methods. We introduce some methods for evaluating drug distribution in the brain. Finally, applications of brain-targeted DDS for the treatment of brain tumors, Alzheimer's disease, Parkinson's disease, and stroke are explained.

中文翻译:

靶向脑药物递送的最新策略。

因为大脑是人体最重要的器官,所以许多脑部疾病都会引起严重的症状。例如,脑瘤的一种类型的神经胶质瘤是进行性和致死性的,而神经退行性疾病会导致严重的残疾。然而,脑疾病的药物治疗仍然不能令人满意,因此需要创新的疗法。但是,由于血脑屏障(BBB)或血脑肿瘤屏障会阻止药物进入大脑,因此难以开发治疗某些脑部疾病的疗法。因此,需要药物输送系统(DDS)策略将治疗药物输送到大脑。最近,已经开发了以脑为靶点的DDS,它提高了脑部疾病的治疗质量。这篇综述概述了近期针对大脑的DDS策略。第一,它描述了跨越BBB的策略。这包括BBB穿越配体修饰或暂时性BBB通透化。还总结了使用本地管理避免BBB的策略。脑内药物分布是直接决定治疗效果的关键因素,因此使用最佳方法评估药物分布很重要。我们介绍了一些评估大脑中药物分布的方法。最后,解释了以脑靶向DDS在治疗脑肿瘤,阿尔茨海默氏病,帕金森氏病和中风方面的应用。脑内药物分布是直接决定治疗效果的关键因素,因此使用最佳方法评估药物分布很重要。我们介绍了一些评估大脑中药物分布的方法。最后,解释了以脑靶向DDS在治疗脑肿瘤,阿尔茨海默氏病,帕金森氏病和中风方面的应用。脑内药物分布是直接决定治疗效果的关键因素,因此使用最佳方法评估药物分布很重要。我们介绍了一些评估大脑中药物分布的方法。最后,解释了以脑靶向DDS在治疗脑肿瘤,阿尔茨海默氏病,帕金森氏病和中风方面的应用。
更新日期:2020-01-01
down
wechat
bug