Introduction: Social Cognition (SC) is a complex construct that reflects a wide variety of implicit and explicit cognitive processes. Many neurocognitive domains are associated with SC and the Executive Function (EF) is the most representative one. We conducted a systematic review aiming at clarifying whether SC impairments are associated with dysfunction on EF in people with Alzheimer Disease (AD).

Methods: The search, based on the Preferred Reporting Items for Systematic Reviews and Meta- Analyses (PRISMA), was undertaken between January 2007 and December 2019 using Pubmed, SciELO, BIREME and Thomson Reuters Web of Science electronic databases. The keywords were SC, AD, EF, Neuropsychological functioning and Executive Disorder.

Results: One hundred thirty-six articles were identified and fifteen were included. These studies are not in agreement about the extent of SC deficits in AD, mainly in the mild stage of the disease. EF deficits, specifically inhibition and the ability to manipulate verbal information, are associated with the impairment in SC in AD. SC decreases with the disease progression, a relationship explained by global cognition impairment and SC specific symptoms.

Conclusion: SC impairment is associated with disease progression, mainly because of the decline in EF. Studies on SC components are unequal, contributing to a frequent generalization of Theory of Mind results, and often hampering the investigation of other components, mainly empathy. More precise knowledge about SC functioning in AD may contribute to a better understanding of the behavioral changes and interpersonal interactions.

中文翻译：

---

阿尔茨海默病社会认知与执行功能之间的关系：系统评价。

简介：社会认知 (SC) 是一个复杂的结构，它反映了各种各样的内隐和外显认知过程。许多神经认知域与 SC 相关，执行功能 (EF) 是最具代表性的一个。我们进行了一项系统评价，旨在阐明 SC 损伤是否与阿尔茨海默病 (AD) 患者的 EF 功能障碍有关。

方法：基于系统评价和荟萃分析首选报告项目 (PRISMA) 的搜索是在 2007 年 1 月至 2019 年 12 月期间使用 Pubmed、SciELO、BIREME 和 Thomson Reuters Web of Science 电子数据库进行的。关键词是 SC、AD、EF、神经心理功能和执行障碍。

结果：共识别出 136 篇文章，包括 15 篇。这些研究对 AD 中 SC 缺陷的程度不一致，主要是在疾病的轻度阶段。EF 缺陷，特别是抑制和操纵语言信息的能力，与 AD 中 SC 的损伤有关。SC随着疾病进展而减少，这种关系可以通过整体认知障碍和SC特定症状来解释。

结论：SC 损伤与疾病进展相关，主要是因为 EF 下降。对 SC 成分的研究是不平等的，导致心智理论结果的频繁概括，并经常妨碍对其他成分的研究，主要是同理心。关于 AD 中 SC 功能的更精确的知识可能有助于更好地理解行为变化和人际交往。