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Active inter-cellular forces in collective cell motility
Journal of The Royal Society Interface ( IF 3.9 ) Pub Date : 2020-08-01 , DOI: 10.1098/rsif.2020.0312
Guanming Zhang 1 , Romain Mueller 1 , Amin Doostmohammadi 2 , Julia M Yeomans 1
Affiliation  

The collective behaviour of confluent cell sheets is strongly influenced both by polar forces, arising through cytoskeletal propulsion, and by active inter-cellular forces, which are mediated by interactions across cell-cell junctions. We use a phase-field model to explore the interplay between these two contributions and compare the dynamics of a cell sheet when the polarity of the cells aligns to (i) their main axis of elongation, (ii) their velocity and (iii) when the polarity direction executes a persistent random walk. In all three cases, we observe a sharp transition from a jammed state (where cell rearrangements are strongly suppressed) to a liquid state (where the cells can move freely relative to each other) when either the polar or the inter-cellular forces are increased. In addition, for case (ii) only, we observe an additional dynamical state, flocking (solid or liquid), where the majority of the cells move in the same direction. The flocking state is seen for strong polar forces, but is destroyed as the strength of the inter-cellular activity is increased.

中文翻译:

集体细胞运动中的活跃细胞间力

融合细胞片的集体行为受到通过细胞骨架推进产生的极性力和由细胞 - 细胞连接处的相互作用介导的活性细胞间力的强烈影响。我们使用相场模型来探索这两个贡献之间的相互作用,并比较当细胞的极性与(i)它们的伸长主轴,(ii)它们的速度和(iii)当极性方向执行持续随机游走。在所有三种情况下,当极性或细胞间力增加时,我们观察到从阻塞状态(细胞重排受到强烈抑制)到液态(细胞可以相对于彼此自由移动)的急剧转变. 此外,仅就情况 (ii) 而言,我们观察到一种额外的动态状态,植绒(固体或液体),其中大多数细胞向同一方向移动。对于强极性力可以看到植绒状态,但随着细胞间活动强度的增加而被破坏。
更新日期:2020-08-01
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