Introduction:

Carbon monoxide (CO) poisoning is a crucial cause of delayed neuropsychiatric syndrome (DNS). However, most biomarkers are not satisfactory for the prediction of DNS caused by CO poisoning. Thus, we evaluated the adequacy of the serum glucose/potassium (GLU/K) ratio, which may be an easy, quick, and readily available parameter that can be used in the emergency department for predicting DNS.

Methods:

We evaluated 281 patients who were admitted to our emergency department between January 2012 and December 2018. The patients were divided into two groups: DNS (+) and DNS (−). The GLU/K was compared for the groups.

Results:

Glucose, blood urea nitrogen, carboxyhemoglobin, and GLU/K ratios of patients in the DNS (+) group were statistically significantly higher than those patients in DNS (−) group (140 ± 34 vs. 110 ± 24, p < 0.001; 17.58 ± 6.14 vs. 14.27 ± 5.08, p = 0.003; 29 ± 5.1 vs. 18.9 ± 7.6, p < 0.001; and 38.35 ± 10.11 vs. 28.65 ± 6.53, p < 0.001, respectively). The area under the curve for GLU/K to predict DNS was measured as 0.791, and 35.9 as a cut-off value had 63.6% sensitivity and 89.6% specificity.

Conclusions:

DNS development in CO poisoning is a serious and feared complication. We suggest that the GLU/K ratio has a high potential as a rapid, easy preliminary marker for the exclusion of patients who will not subsequently develop DNS.

中文翻译：

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评估血清葡萄糖/钾比率作为一氧化碳中毒迟发性神经精神综合征的预测因子。

介绍：

一氧化碳 (CO) 中毒是迟发性神经精神综合征 (DNS) 的重要原因。然而，大多数生物标志物对 CO 中毒引起的 DNS 的预测并不令人满意。因此，我们评估了血清葡萄糖/钾 (GLU/K) 比值的充分性，这可能是一个简单、快速且易于获得的参数，可用于急诊科预测 DNS。

方法：

我们评估了 2012 年 1 月至 2018 年 12 月期间入住我们急诊科的 281 名患者。患者分为两组：DNS (+) 和 DNS (-)。比较各组的 GLU/K。

结果：

DNS (+) 组患者的葡萄糖、血尿素氮、碳氧血红蛋白和 GLU/K 比值在统计学上显着高于 DNS (-) 组患者 (140 ± 34 vs. 110 ± 24, p < 0.001; 17.58 ± 6.14 vs. 14.27 ± 5.08，p = 0.003；29 ± 5.1 vs. 18.9 ± 7.6，p < 0.001；和 38.35 ± 10.11 vs. 28.65 ± 6.53，p < 0.001）。GLU/K 预测 DNS 的曲线下面积测量为 0.791，35.9 作为临界值具有 63.6% 的敏感性和 89.6% 的特异性。

结论：

一氧化碳中毒中的 DNS 发展是一种严重且令人担忧的并发症。我们建议 GLU/K 比率作为快速、简单的初步标志物具有很高的潜力，可用于排除随后不会发展为 DNS 的患者。