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New players on the piRNA field.
Nature Structural & Molecular Biology ( IF 16.8 ) Pub Date : 2020-08-12 , DOI: 10.1038/s41594-020-0484-7
Maria Ninova 1 , Katalin Fejes Tóth 1
Affiliation  

The nuclear piRNA pathway safeguards genome integrity in the germline by silencing transposable elements. Three recent studies have identified new players in the mammalian pathway. Two of these, TEX15 and SPOCD1, might provide a link between piRNA-guided complexes that recognize genomic targets and the molecular machinery that induces DNA methylation and transcriptional repression during mouse spermatogenesis.

中文翻译:

piRNA领域的新参与者。

核piRNA途径通过沉默转座因子来维持种系中的基因组完整性。最近的三项研究确定了哺乳动物途径中的新参与者。其中两个,TEX15和SPOCD1,可能在piRNA引导的识别基因组靶标的复合物与在小鼠精子发生过程中诱导DNA甲基化和转录抑制的分子机制之间建立了联系。
更新日期:2020-08-12
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