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Nanomedicines for Renal Management: From Imaging to Treatment.
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2020-08-12 , DOI: 10.1021/acs.accounts.0c00323 Dawei Jiang 1, 2, 3 , Zachary T Rosenkrans 4 , Dalong Ni 3 , Jing Lin 1 , Peng Huang 1 , Weibo Cai 3, 4
Accounts of Chemical Research ( IF 18.3 ) Pub Date : 2020-08-12 , DOI: 10.1021/acs.accounts.0c00323 Dawei Jiang 1, 2, 3 , Zachary T Rosenkrans 4 , Dalong Ni 3 , Jing Lin 1 , Peng Huang 1 , Weibo Cai 3, 4
Affiliation
Nanomedicine has benefited from recent advances in chemistry and biomedical engineering to produce nanoscale materials as theranostic agents. Well-designed nanomaterials may present optimal biological properties, influencing circulation, retention, and excretion for imaging and treatment of various diseases. As the understanding of nanomedicine pharmacokinetics expands continuously, efficient renal clearance of nanomedicines can significantly increase the signal-to-background ratio for precision diagnosis and lower potential toxicity for improved treatment. Studies on nanomaterial–kidney interactions have led to many novel findings on the underlying principles of nanomaterial renal clearance, targeting, and accumulation. In return, the optimized nanomedicines confer significant benefits to the detection and treatment of kidney dysfunction.
中文翻译:
肾脏管理纳米药物:从成像到治疗。
纳米医学受益于化学和生物医学工程的最新进展,以生产纳米材料作为治疗诊断剂。精心设计的纳米材料可能具有最佳的生物学特性,影响循环、滞留和排泄,用于各种疾病的成像和治疗。随着对纳米药物药代动力学的理解不断扩大,纳米药物的有效肾脏清除可以显着提高精确诊断的信噪比,并降低潜在毒性以改善治疗。对纳米材料-肾脏相互作用的研究导致了许多关于纳米材料肾脏清除、靶向和积累的基本原理的新发现。作为回报,优化的纳米药物为肾功能障碍的检测和治疗带来了显着的好处。
更新日期:2020-09-15
中文翻译:
肾脏管理纳米药物:从成像到治疗。
纳米医学受益于化学和生物医学工程的最新进展,以生产纳米材料作为治疗诊断剂。精心设计的纳米材料可能具有最佳的生物学特性,影响循环、滞留和排泄,用于各种疾病的成像和治疗。随着对纳米药物药代动力学的理解不断扩大,纳米药物的有效肾脏清除可以显着提高精确诊断的信噪比,并降低潜在毒性以改善治疗。对纳米材料-肾脏相互作用的研究导致了许多关于纳米材料肾脏清除、靶向和积累的基本原理的新发现。作为回报,优化的纳米药物为肾功能障碍的检测和治疗带来了显着的好处。