ABSTRACT The most limiting features of titanium as a bone substituent are lack of bioactivity and high Young’s modulus. We have prepared titanium-hydroxyapatite (Ti-HAp) composites using titanium hydride as sintering agent to provide titanium sintering at lower temperature and preserve the stability of apatite phase. After low temperature sintering, no hydroxyapatite decomposition was detected. Pure titanium samples sintered in the presence of hydride showed smooth surface indicating good densification at 800°C. Higher HAp content resulted in decreased density and higher porosity due to the formation of micro- and macro-pores caused by the integration of HAp particles into titanium matrix and titanium hydride decomposition. However, Vickers microhardness test showed increased hardness for Ti-HAp composite with 10% of HAp regarding pure Ti. The bioactivity of Ti-HAp composites evaluated in simulated body fluid significantly improved with HAp content. The presence of HAp has lowered the cytotoxic effect of Ti-based composites on Hek293 cells.

中文翻译：

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低温烧结钛-墨鱼骨羟基磷灰石复合材料的生物活性

摘要 钛作为骨替代物的最大限制特征是缺乏生物活性和高杨氏模量。我们使用氢化钛作为烧结剂制备了钛-羟基磷灰石（Ti-HAp）复合材料，以提供较低温度下的钛烧结并保持磷灰石相的稳定性。低温烧结后，未检测到羟基磷灰石分解。在氢化物存在下烧结的纯钛样品显示出光滑的表面，表明在 800°C 下具有良好的致密性。由于 HAp 颗粒整合到钛基体中和氢化钛分解导致形成微孔和大孔，因此较高的 HAp 含量导致密度降低和孔隙率升高。然而，维氏显微硬度测试表明，对于纯钛，含 10% HAp 的 Ti-HAp 复合材料硬度增加。在模拟体液中评估的 Ti-HAp 复合材料的生物活性随着 HAp 含量的增加而显着提高。HAp 的存在降低了钛基复合材料对 Hek293 细胞的细胞毒性作用。