ABSTRACT

As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst. The chaperoning function is found intrinsic to ribozymes involved in protein synthesis and tRNA maturation, enriching the primordial RNA world with proteins of biological relevance. The ribozyme-resident protein folding activity, even before the advent of protein-based molecular chaperone, must have expedited the transition of the RNA world into the present protein theatre.

中文翻译：

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Chaperna：连接古老的 RNA 和蛋白质世界。

摘要

作为自我复制生物形态转变的心理框架，RNA世界概念规定了RNA作为遗传物质和催化剂的双重功能。分子伴侣功能是参与蛋白质合成和 tRNA 成熟的核酶所固有的，用具有生物相关性的蛋白质丰富了原始 RNA 世界。甚至在基于蛋白质的分子伴侣出现之前，核酶驻留的蛋白质折叠活性肯定已经加速了 RNA 世界向当前蛋白质剧院的转变。