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Evaluation of a regional nerve block with an experimental formulation of encapsulated lidocaine in sheep.
Veterinary Anaesthesia and Analgesia ( IF 1.7 ) Pub Date : 2020-08-12 , DOI: 10.1016/j.vaa.2020.07.036
Erika A Militana 1 , Luis Campoy 1 , Manuel Martin-Flores 1 , Robin D Gleed 1
Affiliation  

Objective

To compare the duration of nociceptive and proprioceptive blockade from an experimental encapsulated lidocaine preparation with that of conventional lidocaine.

Study design

Prospective, blinded, randomly assigned, crossover study.

Animals

A total of six adult Dorset ewes, American Society of Anesthesiologists physical status I or II, weighing 60.4 ± 18.0 kg (mean ± standard deviation).

Methods

Under general anesthesia and guided by electrolocation, the common peroneal nerve was blocked unilaterally with encapsulated lidocaine (0.1 mL kg–1, 200 mg mL–1) or conventional lidocaine hydrochloride (0.1 mL kg–1, 20 mg mL–1). Each sheep was administered both treatments with an interval of 2 weeks between treatments. Nociception and proprioception were scored (scales of 0–3) before anesthesia, at 0.5, 1, 2, 4, 8, 12, 16, 20 and 24 hours after completion of local anesthetic injection, and every 12 hours thereafter for 9 days. Nociceptive and proprioceptive blockade ended the first time each score reached ‘0’; maximum blockade duration was considered and recorded to be the time point immediately prior to this end point. Significance of differences between treatments for duration of blockade was tested with the Wilcoxon rank-sum test. Effects of time and treatment on nociceptive and proprioceptive blockade were evaluated with mixed-effect models. Significance was set at p < 0.05.

Results

Compared with conventional lidocaine, nociceptive blockade lasted 88 hours longer with encapsulated lidocaine (p = 0.008), and proprioceptive blockade lasted 6 hours longer (p = 0.03). Significant effects of time (p < 0.0001), treatment (p = 0.0435) and treatment∗time (p < 0.0001) were observed for nociception. Significant effects of time (p < 0.0001) and treatment∗time (p = 0.0058) were observed for proprioception.

Conclusion

Encapsulated lidocaine produced nociceptive blockade with a duration substantially longer than conventional lidocaine.

Clinical relevance

Sustained-release encapsulated lidocaine alleviates pain and may minimize systemic analgesic use.



中文翻译:

用绵羊封装的利多卡因的实验配方评估局部神经阻滞。

目的

为了比较实验性胶囊化利多卡因制剂与常规利多卡因制剂的伤害性和本体感受性阻断作用的持续时间。

学习规划

前瞻性,盲法,随机分配,交叉研究。

动物

美国麻醉医师学会的六只成年多塞特成年母羊的身体状况I或II,体重为60.4±18.0千克(平均±标准差)。

方法

在全身麻醉下,并通过电磁定位引导,腓总神经用包封利多卡因(0.1毫升公斤单方面阻塞-1,200毫克毫升-1)或常规盐酸利多卡因(0.1毫升千克-1,20毫克毫升-1)。每只绵羊均接受两次治疗,两次治疗之间的间隔为2周。麻醉前,局部麻醉注射完成后0.5、1、2、4、8、12、16、20和24小时,以及之后每12小时(共9天)对伤害感受和本体感受进行评分(0-3级)。伤害性和本体感受性阻滞在每次得分均达到“ 0”时首次结束。考虑了最大封锁持续时间,并将其记录为该终点之前的时间点。使用Wilcoxon秩和检验检验了两种疗法在封锁持续时间上的差异。用混合效应模型评估了时间和治疗对伤害感受和本体感受阻滞的影响。显着性设定为p<0.05。

结果

与传统的利多卡因相比,使用利多卡因胶囊进行的伤害性阻断持续时间延长了88小时(p  = 0.008),而本体感受性的阻断持续时间延长了6小时(p  = 0.03)。对于伤害感受,观察到时间(p <0.0001),治疗(p  = 0.0435)和治疗*时间(p <0.0001)的显着影响。 对于本体感受,观察到时间(p <0.0001)和治疗时间(p = 0.0058)的显着影响。

结论

封装的利多卡因产生伤害性阻断作用,其持续时间明显长于常规利多卡因。

临床相关性

缓释胶囊化利多卡因可减轻疼痛,并可最大程度减少全身镇痛剂的使用。

更新日期:2020-08-12
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