当前位置: X-MOL 学术J. Mol. Struct. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Copper(II) and Nickel(II) complexes of the non-steroidal anti-inflammatory drug indomethacin containing aromatic chelating N,N-donor ligand: Synthesis and Structural studies
Journal of Molecular Structure ( IF 3.8 ) Pub Date : 2021-01-01 , DOI: 10.1016/j.molstruc.2020.129069
Ginikachukwu G. Nnabuike , Sunita Salunke-Gawali , Archana S. Patil , Ray J. Butcher , Misitura Lawal , Mercy O. Bamigboye , Joshua A. Obaleye

Abstract Two complexes [Cu(indo)2(phen)(H2O)];Cu-1 and [Ni(indo)2(phen)(H2O)2].1.5H2O;Ni-1, were synthesized by the reaction of their respective metal(II)acetates with indomethacin (indo) [1-(4-chlorobenzoyl)-5‑methoxy‑2-methyl-1H-indole-3-acetic acid)] and a nitrogen donor heterocyclic ligand 1,10-phenanthroline (phen) in acetonitrile: water mixture (9:1 v/v), by refluxing at 80 °C for 3 h. The complexes were characterized by physicochemical, spectroscopic, and TG analysis. X-ray structural analysis showed that both complexes crystallizes in the triclinic space group P-1. Cu-1 consists of Cu(II) in square pyramidal geometry and coordinated to two monodentate indomethacin ligands, a bidentate 1,10-phenanthroline, and one aqua ligand. Intermolecular O-H···O, C-H···O, C-H···Cl, Cl···Cl, and C-H···π interactions in Cu-1 were responsible for the stability of the complex. Ni-1 is centrosymmetric and consists of Ni(II) in a distorted octahedral geometry, involving two trans monodentate indomethacin ligands, a bidentate 1,10-phenanthroline ligand, and two cis aqua ligands. There were two lattice water molecules outside the coordination sphere of Ni-1, that participated in extensive O-H···O interactions. The complex was further stabilized by C-H···O, C-H···π, and π···π interactions. The monodentate coordination of the carboxylato oxygen of indomethacin ligand in the complexes was confirmed from the FTIR studies. TG analysis provided information on the stability and decomposition pattern of the complexes.

中文翻译:

含有芳香螯合 N,N-供体配体的非甾体抗炎药吲哚美辛的铜 (II) 和镍 (II) 配合物:合成和结构研究

摘要 通过反应合成了两种配合物 [Cu(indo)2(phen)(H2O)];Cu-1 和 [Ni(indo)2(phen)(H2O)2].1.5H2O;Ni-1。相应的金属(II)乙酸盐与吲哚美辛(indo)[1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-1H-吲哚-3-乙酸)]和氮供体杂环配体1,10-菲咯啉( phen) 在乙腈:水混合物 (9:1 v/v) 中,在 80 °C 下回流 3 小时。通过物理化学、光谱和TG分析表征复合物。X 射线结构分析表明,这两种配合物都在三斜空间群 P-1 中结晶。Cu-1 由四方锥体几何形状的 Cu(II) 组成,并与两个单齿吲哚美辛配体、一个双齿 1,10-菲咯啉和一个水配体配位。分子间OH…O, CH…O, CH…Cl, Cl…Cl, Cu-1中的CH···π相互作用是配合物稳定性的原因。Ni-1 是中心对称的,由扭曲八面体几何形状的 Ni(II) 组成,涉及两个反式单齿吲哚美辛配体、一个双齿 1,10-菲咯啉配体和两个顺式 aqua 配体。Ni-1配位球外有两个晶格水分子,参与了广泛的OH···O相互作用。CH···O、CH···π、π···π相互作用进一步稳定了配合物。FTIR 研究证实了配合物中吲哚美辛配体的羧基氧的单齿配位。TG 分析提供了关于复合物稳定性和分解模式的信息。涉及两个反式单齿吲哚美辛配体、一个双齿 1,10-菲咯啉配体和两个顺式 aqua 配体。Ni-1配位球外有两个晶格水分子,参与了广泛的OH···O相互作用。CH···O、CH···π、π···π相互作用进一步稳定了配合物。FTIR 研究证实了配合物中吲哚美辛配体的羧基氧的单齿配位。TG 分析提供了关于复合物稳定性和分解模式的信息。涉及两个反式单齿吲哚美辛配体、一个双齿 1,10-菲咯啉配体和两个顺式 aqua 配体。Ni-1配位球外有两个晶格水分子,参与了广泛的OH···O相互作用。CH···O、CH···π、π···π相互作用进一步稳定了配合物。FTIR 研究证实了配合物中吲哚美辛配体的羧基氧的单齿配位。TG 分析提供了关于复合物稳定性和分解模式的信息。FTIR 研究证实了配合物中吲哚美辛配体的羧基氧的单齿配位。TG 分析提供了关于复合物稳定性和分解模式的信息。FTIR 研究证实了配合物中吲哚美辛配体的羧基氧的单齿配位。TG 分析提供了关于复合物稳定性和分解模式的信息。
更新日期:2021-01-01
down
wechat
bug