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Performance of ceftriaxone susceptibility testing on the Accelerate Pheno® system of ESBL-producing isolates.
Diagnostic Microbiology and Infectious Disease ( IF 2.9 ) Pub Date : 2020-08-12 , DOI: 10.1016/j.diagmicrobio.2020.115171
Amira A Bhalodi 1 , Paul Magnano 1 , Romney M Humphries 2
Affiliation  

The correlation of ceftriaxone nonsusceptibility and ESBL production was evaluated in 40 characterized isolates. Performance of ceftriaxone susceptibility testing on the Accelerate Pheno was evaluated and compared with reference broth microdilution in triplicate. The CLSI ESBL confirmatory test was also evaluated. Ceftriaxone categorical agreement of the Accelerate Pheno was 97.5% with 1 minor error. The ESBL confirmatory disk test resulted in 4 false-negatives and 1 false positive. The Accelerate Pheno provides an expedited and accurate method of ceftriaxone susceptibility testing allowing for optimization of antimicrobial regimens sooner. These data indicate that ESBL production has a high likelihood of ceftriaxone non-susceptibility.



中文翻译:

在生产ESBL的分离株的AcceleratePheno®系统上进行头孢曲松敏感性测试。

头孢曲松非药敏性与ESBL产生的相关性在40个特征分离株中进行了评估。评估了头孢曲松药敏试验在加速Pheno上的性能,并将其与参考肉汤微量稀释液一式三份进行了比较。还评估了CLSI ESBL确认测试。加速Pheno的头孢曲松钠分类一致性为97.5%,有1个小错误。ESBL验证性磁盘测试导致4例假阴性和1例假阳性。Accelerate Pheno提供了一种快速,准确的头孢曲松敏感性试验方法,可以更快地优化抗菌方案。这些数据表明,ESBL的生产具有很高的头孢曲松敏感性。

更新日期:2020-09-11
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