Systemic arterial hypertension (SAH) is a major health problem around the world and its development has been associated with exceeding salt consumption by the modern society. The mechanisms by which salt consumption increase blood pressure (BP) involve several homeostatic systems but many details have not yet been fully elucidated. Evidences accumulated over the last 60 decades raised the involvement of the immune system in the hypertension development and opened a range of possibilities for new therapeutic targets. Green propolis is a promising natural product with potent anti-inflammatory properties acting on specific targets, most of them participating in the gut–brain axis of the sodium-dependent hypertension. New anti-hypertensive products reinforce the therapeutic arsenal improving the corollary of choices, especially in those cases where patients are resistant or refractory to conventional therapy. This review sought to bring the newest advances in the field articulating evidences that show a cross-talking between inflammation and the central mechanisms involved with the sodium-dependent hypertension as well as the stablished actions of green propolis and some of its biologically active compounds on the immune cells and cytokines that would be involved with its anti-hypertensive properties.

系统性动脉高血压 (SAH) 是世界范围内的主要健康问题，其发展与现代社会过度食用盐有关。盐消耗增加血压 (BP) 的机制涉及多个稳态系统，但许多细节尚未完全阐明。过去 60 年积累的证据提高了免疫系统在高血压发展中的作用，并为新的治疗靶点开辟了一系列可能性。绿色蜂胶是一种很有前途的天然产物，具有作用于特定目标的有效抗炎特性，其中大多数参与钠依赖性高血压的肠-脑轴。新的抗高血压产品加强了治疗手段，改善了选择的必然结果，特别是在患者对常规治疗耐药或难治的情况下。这篇综述试图带来该领域的最新进展，阐明证据表明炎症与钠依赖性高血压相关的中枢机制之间存在交叉对话，以及绿蜂胶及其一些生物活性化合物对免疫细胞和细胞因子将与其抗高血压特性有关。