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Trend of clinical vancomycin-resistant enterococci isolated in a regional Italian hospital from 2001 to 2018
Brazilian Journal of Microbiology ( IF 2.2 ) Pub Date : 2020-08-11 , DOI: 10.1007/s42770-020-00360-8
Simona Fioriti 1 , Serena Simoni 2 , Sara Caucci 1 , Gianluca Morroni 1 , Elisa Ponzio 3 , Sonia Nina Coccitto 1 , Lucia Brescini 4 , Oscar Cirioni 4 , Stefano Menzo 1 , Francesca Biavasco 2 , Eleonora Giovanetti 2 , Andrea Brenciani 1 , Carla Vignaroli 2
Affiliation  

A retrospective study of the epidemiology of vancomycin-resistant enterococci (VRE) in a regional hospital of central Italy in 2001-2018 demonstrated an increased VRE prevalence since 2016. A total of 113 VRE isolates, 89 E. faecium (VREfm) and 24 E. faecalis (VREfs), were collected in the study period. All strains showed high-level resistance to vancomycin; 107 also showed teicoplanin resistance. Altogether, 84 VREfm and 20 VREfs carried vanA, whereas 5 VREfm and 1 VREfs carried vanB. MLST analysis documented that 89 VREfm isolates mainly belonged to ST78, ST80, and ST117. Most strains were isolated from 2001 to 2007, ST78 being the predominant clone. VREfm re-emerged in 2016 with a prevalence of the ST80 lineage. Most VREfs were isolated from 2001 to 2006; although they belonged to 7 different STs, there was a prevalence of ST88 and ST6. Notably, ST88 was sporadically recovered throughout the study period. The increasing rate of VREfm isolation from 2016 to 2018 may be related to the influx of new successful clones and to the renewed and widespread use of vancomycin. Improved infection control measures in hospital wards should be adopted to limit the spread of new epidemic VRE strains.

中文翻译:

2001-2018年意大利某地区医院临床分离出的耐万古霉素肠球菌趋势

2001-2018 年意大利中部地区医院对万古霉素耐药肠球菌 (VRE) 流行病学的回顾性研究表明,自 2016 年以来 VRE 流行率有所增加。 共有 113 株 VRE 分离株,89 株屎肠球菌 (VREfm) 和 24 株大肠杆菌. 粪便 (VREf),在研究期间收集。所有菌株对万古霉素均表现出高度耐药性;107 也表现出对替考拉宁的耐药性。总共有 84 个 VREfm 和 20 个 VREfs 携带 vanA,而 5 个 VREfm 和 1 个 VREfs 携带 vanB。MLST 分析记录了 89 个 VREfm 分离株主要属于 ST78、ST80 和 ST117。大多数菌株是从 2001 年到 2007 年分离的,其中 ST78 是主要克隆。随着 ST80 谱系的流行,VRefm 于 2016 年重新出现。大多数 VREf 是从 2001 年到 2006 年分离出来的;尽管它们属于 7 个不同的 ST,但 ST88 和 ST6 普遍存在。尤其,在整个研究期间,ST88 偶尔会被回收。从 2016 年到 2018 年,VREfm 分离率的增加可能与新的成功克隆的涌入以及万古霉素的重新和广泛使用有关。应在医院病房采取改进的感染控制措施,以限制新的流行性 VRE 毒株的传播。
更新日期:2020-08-11
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