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The Theory of Chemical Symbiosis: A Margulian View for the Emergence of Biological Systems (Origin of Life)
Acta Biotheoretica ( IF 1.3 ) Pub Date : 2020-08-11 , DOI: 10.1007/s10441-020-09388-7
Francisco Prosdocimi 1, 2 , Marco V José 2 , Sávio Torres de Farias 3
Affiliation  

The theory of chemical symbiosis (TCS) suggests that biological systems started with the collaboration of two polymeric molecules existing in early Earth: nucleic acids and peptides. Chemical symbiosis emerged when RNA-like nucleic acid polymers happened to fold into 3D structures capable to bind amino acids together, forming a proto peptidyl-transferase center. This folding catalyzed the formation of quasi-random small peptides, some of them capable to bind this ribozyme structure back and starting to form an initial layer that would produce the larger subunit of the ribosome by accretion. TCS suggests that there is no chicken-and-egg problem into the emergence of biological systems as RNAs and peptides were of equal importance to the origin of life. Life has initially emerged when these two macromolecules started to interact in molecular symbiosis. Further, we suggest that life evolved into progenotes and cells due to the emergence of new layers of symbiosis. Mutualism is the strongest force in biology, capable to create novelties by emergent principles; on which the whole is bigger than the sum of the parts. TCS aims to apply the Margulian view of biology into the origins of life field.

中文翻译:

化学共生理论:对生物系统(生命起源)出现的马古利安观点

化学共生 (TCS) 理论表明,生物系统始于地球早期存在的两种聚合物分子的协作:核酸和肽。当 RNA 样核酸聚合物碰巧折叠成能够将氨基酸结合在一起的 3D 结构时,化学共生就出现了,形成了一个原肽基转移酶中心。这种折叠催化了准随机小肽的形成,其中一些能够重新结合这种核酶结构并开始形成初始层,该层将通过增生产生更大的核糖体亚基。TCS 表明,生物系统的出现不存在先有鸡还是先有蛋的问题,因为 RNA 和肽对于生命的起源同等重要。当这两种大分子开始在分子共生中相互作用时,生命最初就出现了。此外,我们认为,由于新的共生层的出现,生命进化为后代和细胞。互惠是生物学中最强大的力量,能够通过涌现的原理创造新事物;其中整体大于部分之和。TCS旨在将Margulian的生物学观点应用于生命起源领域。
更新日期:2020-08-11
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