Nontoxic adhesive hydrogels are of great importance in tissue engineering. Herein, we report a simple synthesis of a few biocompatible hydrogels from adenine and dopamine immobilized polyacrylic acid (PAA) and alginic acid (Alg) polymers. The adenine–dopamine adduct incorporated hydrogels showed enhanced adhesiveness, transparency and biocompatibility, and induced cell proliferation in 2D and 3D-cell culture models within 24 h. Moreover, blending the modified PAA and Alg polymers (P2P4) further increased the stability and bioactivity of the hydrogel. Such biogels can be developed as smart materials for biomedical applications.

中文翻译：

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生物启发的腺嘌呤-多巴胺固定聚合物水凝胶粘合剂，用于组织工程。

无毒的粘性水凝胶在组织工程中非常重要。本文中，我们报道了由腺嘌呤和多巴胺固定的聚丙烯酸（PAA）和藻酸（Alg）聚合物简单合成了几种生物相容性水凝胶。掺入了腺嘌呤-多巴胺加合物的水凝胶在24小时内在2D和3D细胞培养模型中显示出增强的粘附性，透明性和生物相容性，并诱导了细胞增殖。此外，将改性的PAA和Alg聚合物（P2P4）掺混可进一步提高水凝胶的稳定性和生物活性。这样的生物凝胶可以被开发为用于生物医学应用的智能材料。