Water-soluble amphiphiles may, above a certain concentration, form colloidal aggregates (micelles or liquid crystals). If such aggregates are formed, there may be a competition between the micelles or the liquid crystals and the biological target for the monomelic form of the amphiphile. This may reduce the number of monomers available for the biological target, which in turn may be reflected in concentration-dependent processes. Therefore, caution should be taken when examining dose-response with soluble amphiphiles forming micelles at low concentrations.

中文翻译：

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由于可溶性两亲化合物的缔合胶体行为引起的反常剂量反应关系

水溶性两亲物在超过一定浓度时可能形成胶体聚集体（胶束或液晶）。如果形成这样的聚集体，胶束或液晶与两亲物单体形式的生物靶标之间可能存在竞争。这可能会减少可用于生物目标的单体数量，这反过来可能反映在浓度依赖性过程中。因此，在检测可溶性两亲物在低浓度下形成胶束时的剂量反应时应谨慎。