Primary astroglial cell cultures from neonatal rat cerebral cortex revealed morphological changes when incubated in HgCl2 at various concentrations. After incubation for 30 minutes with 5 x 10-6 HgCl2, most cells changed their form from a flat to a more rounded shape and extended processes. After longer incubations (>60 minutes) or at higher concentrations (≥10-5M), vacuoles appeared in many cells. [3H]-Thymidine incorporation into DNA was slightly increased after acute incubation in 10-9M HgCl2, while decreases were obtained after incubation in the μM range. The results are important due to the functions of astroglia during development and in the mature nervous system.

中文翻译：

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氯化汞影响形态学和胸苷掺入培养星形胶质细胞中的 DNA

新生大鼠大脑皮层的原代星形胶质细胞培养物在不同浓度的 HgCl2 中培养时显示出形态学变化。与 5 x 10-6 HgCl2 孵育 30 分钟后，大多数细胞的形状从扁平状变为更圆润的形状并延长了过程。在更长的孵育时间（>60 分钟）或更高浓度（≥10-5M）后，许多细胞中出现液泡。在 10-9M HgCl2 中急性孵育后 [3H]-胸苷掺入 DNA 略有增加，而在 μM 范围内孵育后则减少。由于星形胶质细胞在发育过程中和成熟神经系统中的功能，结果很重要。