Tests, performed over a ten-year period, on 653 polymers intended for use in extracorporeal renal replacement therapy, were evaluated. The test battery used included animal tests, in vitro tests and chemical tests. Some tests were found to have a very low sensitivity. Thus, acute systemic toxicity testing in mice with sodium chloride, ethanol or paraffin oil as extractants was performed on a total of 806 occasions. Only two of these resulted in a “fail” decision. The final outcome of the tests for the majority of materials could be predicted by the results of the UV absorption, chloride, inhibition of cell growth, and tin tests. Of the materials that passed these four tests, less than 2% were not approved on the basis of the whole test battery. The experiments show that only a limited number of tests have to be performed when testing polymers intended for use in extracorporeal renal replacement therapy.

中文翻译：

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高分子材料的测试：应该使用什么方法？

对用于体外肾脏替代疗法的 653 种聚合物进行了 10 年的测试进行了评估。使用的测试电池包括动物测试、体外测试和化学测试。一些测试被发现具有非常低的灵敏度。因此，以氯化钠、乙醇或石蜡油为提取剂的小鼠急性全身毒性试验共进行了 806 次。其中只有两个导致“失败”的决定。大多数材料测试的最终结果可以通过紫外线吸收、氯化物、细胞生长抑制和锡测试的结果来预测。在通过这四项测试的材料中，以整个测试电池为基准，不合格的不到2%。