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Associations of Breast Milk Consumption with Urinary Phthalate and Phenol Exposure Biomarkers in Infants
Environmental Science & Technology Letters ( IF 10.9 ) Pub Date : 2020-08-11 , DOI: 10.1021/acs.estlett.0c00450
Noelle B. Henderson 1 , Clara G. Sears 1 , Antonia Calafat 2 , Aimin Chen 3 , Bruce Lanphear 4 , Megan Romano 5 , Kimberly Yolton 6, 7 , Joseph M. Braun 1
Affiliation  

Phthalates and phenols are readily detected in human breast milk, but the contribution of breast milk feeding to an infant’s exposure to these chemicals is unknown. Among 248 mother–infant pairs in the HOME Study, we assessed breast milk consumption via maternal report and quantified concentrations of eight phthalate metabolites and three phenols (bisphenol A, triclosan, benzophenone-3) in infants’ urine at age 12 months. We estimated covariate-adjusted percent differences in phthalate metabolite and phenol concentrations by breast milk consumption. Seventy infants (28%) were fed some breast milk up to age 12 months. Urinary phenol concentrations were similar in infants who were or were not fed breast milk at 12 months. In contrast, urinary concentrations of monocarboxyisooctyl phthalate (MCOP) and mono-3-carboxypropyl phthalate (MCPP) were 42% (95% CI: 3, 97) and 24% (95% CI: −8, 62) higher among infants fed breast milk at 12 months, respectively. Moreover, MCOP and MCPP concentrations were positively associated with the quantity of breast milk consumed in the prior month and 24 h. In this cohort, we found evidence suggesting that breast milk consumption may be a source of exposure to some phthalates. Future studies should examine whether plastic feeding bottles or pumped milk is a potential exposure source among infants.

中文翻译:

母乳喂养与婴儿邻苯二甲酸酯和苯酚暴露生物标志物的关系

在人母乳中很容易检测到邻苯二甲酸盐和苯酚,但母乳喂养对婴儿接触这些化学物质的影响尚不清楚。在HOME研究中的248对母婴中,我们通过母体报告评估了母乳的摄入量,并对12个月大的婴儿尿液中8种邻苯二甲酸酯代谢物和3种酚(双酚A,三氯生,二苯甲酮3)的定量浓度进行了评估。我们估计了母乳消耗量对邻苯二甲酸酯代谢物和苯酚浓度的协变量调整百分比差异。70名婴儿(占28%)被喂一些母乳,直到12个月大。12个月未喂母乳的婴儿的尿酚浓度相似。相反,在母乳喂养的婴儿中,邻苯二甲酸单羧异辛酯(MCOP)和邻苯二甲酸单-3-羧丙基酯(MCPP)的尿液浓度分别高42%(95%CI:3,97)和24%(95%CI:-8、62)。分别为12个月。此外,MCOP和MCPP浓度与前一个月和24小时内所消耗的母乳量呈正相关。在这一队列中,我们发现证据表明母乳消耗可能是接触邻苯二甲酸盐的来源。未来的研究应检查塑料奶瓶或抽奶是否是婴儿潜在的接触源。我们发现有证据表明,母乳消费可能是接触某些邻苯二甲酸盐的来源。未来的研究应检查塑料奶瓶或抽奶是否是婴儿潜在的接触源。我们发现有证据表明,母乳消费可能是接触某些邻苯二甲酸盐的来源。未来的研究应检查塑料奶瓶或抽奶是否是婴儿潜在的接触源。
更新日期:2020-10-13
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