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Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis.
Bioconjugate Chemistry ( IF 4.7 ) Pub Date : 2020-08-10 , DOI: 10.1021/acs.bioconjchem.0c00395
Serge Mignani 1, 2, 3 , Xiangyang Shi 2, 4 , João Rodrigues 2, 5 , René Roy 3 , Ángeles Muñoz-Fernández 6 , Valentin Ceña 7 , Jean-Pierre Majoral 8, 9
Affiliation  

The goal of nanomedicine is to address specific clinical problems optimally, to fight human diseases, and to find clinical relevance to change clinical practice. Nanomedicine is poised to revolutionize medicine via the development of more precise diagnostic and therapeutic tools. The field of nanomedicine encompasses numerous features and therapeutic disciplines. A plethora of nanomolecular structures have been engineered and developed for therapeutic applications based on their multitasking abilities and the wide functionalization of their core scaffolds and surface groups. Within nanoparticles used for nanomedicine, dendrimers as well polymers have demonstrated strong potential as nanocarriers, therapeutic agents, and imaging contrast agents. In this review, we present and discuss the different criteria and parameters to be addressed to prepare and develop druggable nanoparticles in general and dendrimers in particular. We also describe the major requirements, included in the preclinical and clinical roadmap, for NPs/dendrimers for the preclinical stage to commercialization. Ultimately, we raise the clinical translation of new nanomedicine issues.

中文翻译:

树枝状大分子对转化的纳米治疗学:关键步骤分析。

纳米医学的目标是最佳地解决特定的临床问题,与人类疾病作斗争,并找到与临床相关的改变临床实践。纳米医学将通过开发更精确的诊断和治疗工具来彻底改变医学。纳米医学领域涵盖众多特征和治疗学科。基于它们的多任务处理能力以及其核心支架和表面基团的广泛功能性,已经为治疗应用设计和开发了多种纳米分子结构。在用于纳米医学的纳米颗粒中,树枝状聚合物以及聚合物已证明具有作为纳米载体,治疗剂和成像造影剂的强大潜力。在这篇评论中 我们提出并讨论了准备和开发一般可药物合成的纳米颗粒,特别是树枝状聚合物所要解决的不同标准和参数。我们还描述了临床前到商业化阶段NP /树状聚合物的主要要求,包括在临床前和临床路线图中。最终,我们提出了新的纳米医学问题的临床翻译。
更新日期:2020-09-16
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