Multiple studies have assessed the contribution of rs10490924 on chromosome 10q26 surrounding HTRA1/ARMS2 gene to age-related macular degeneration (AMD) risk. However, the causal allele at this locus is still inconclusive. In this meta-analysis, we systematically characterized the potential association between rs10490924 polymorphism and AMD risk. Data available from 12 case-control studies, including a total of 5244 cases and 2755 controls in three different ethnic populations, were used to evaluate the correlation between rs10490924 G/T polymorphism (Ala69Ser) and AMD risk. In overall populations, the results indicated the Ala69Ser polymorphism was significantly associated with AMD under allelic (OR = 0.35, 95% CI = 0.30-0.40), homozygous (OR = 0.12, 95%CI = 0.09-0.17), dominant (OR = 0.18, 95%CI = 0.14-0.24), recessive (OR = 0.33, 95%CI = 0.28-0.39), and heterozygous genetic models (OR = 0.26, 95% CI = 0.21-0.33). Similar results were observed in subgroup analysis. This meta-analysis suggests that rs10490924 (Ala69Ser) polymorphism was significantly associated with the susceptibility of AMD in all ethnicities, Ala69 carriers are resistant to AMD risk.

中文翻译：

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rs10490924 围绕 HTRA1/ARMS2 调节与年龄相关的黄斑变性的易感性

多项研究评估了 rs10490924 在 HTRA1/ARMS2 基因周围的染色体 10q26 上对年龄相关性黄斑变性 (AMD) 风险的贡献。然而，该位点的因果等位基因仍然没有定论。在这项荟萃分析中，我们系统地描述了 rs10490924 多态性与 AMD 风险之间的潜在关联。来自 12 项病例对照研究的数据，包括三个不同种族人群中的 5244 例病例和 2755 例对照，用于评估 rs10490924 G/T 多态性 (Ala69Ser) 与 AMD 风险之间的相关性。在总体人群中，结果表明 Ala69Ser 多态性在等位基因 (OR = 0.35, 95% CI = 0.30-0.40)、纯合子 (OR = 0.12, 95%CI = 0.09-0.17)、显性 (OR = 0.09-0.17) 下与 AMD 显着相关0.18, 95%CI = 0.14-0.24)，隐性（OR = 0.33, 95%CI = 0。28-0.39）和杂合遗传模型（OR = 0.26，95% CI = 0.21-0.33）。在亚组分析中观察到类似的结果。该荟萃分析表明 rs10490924 (Ala69Ser) 多态性与所有种族的 AMD 易感性显着相关，Ala69 携带者对 AMD 风险具有抵抗力。