Tetracycline residues have frequently been detected in multi-environmental media, and it could induce antibiotic resistance genes (ARGs) in microorganisms, which has attracted great attention. Where biodegradation processes may be a promising strategy to remove tetracycline. Thus, this study mainly considers: (i) the degradation of tetracycline by microorganisms including single microorganisms and microbial flora; (ii) the elimination of tetracycline during biochemical treatment processes and advanced treatment systems in wastewater treatment plants (WWTPs) and constructed wetlands (CWs); (iii) the degradation of tetracycline by biological coupling processes; (iv) the confusion and problem of tetracycline biodegradation. Furthermore, the characteristics and comparison of tetracycline biodegradation have been discussed in detail. Additionally, future research directions are suggested to reduce tetracycline in the aquatic environment, especially tetracycline biodegradation and the nitrogen conversion process.

• Highlights

• Degradation of tetracycline by pure culture strains and microflora was significant.

• Degradation of tetracycline by biochemical treatment process was summarized.

• Advanced treatment process in CWs could eliminate tetracycline.

• Future research directions on biodegradation of tetracycline are proposed.

四环素残留物经常在多种环境介质中被检测到，并且可以诱导微生物中的抗生素抗性基因（ARGs），引起了极大的关注。生物降解过程可能是去除四环素的有前途的策略。因此，本研究主要考虑：（i）微生物（包括单一微生物和微生物菌群）对四环素的降解；（ii）在废水处理厂（WWTP）和人工湿地（CW）的生化处理过程和高级处理系统中消除四环素；（iii）通过生物偶联过程降解四环素；（iv）四环素生物降解的困惑和问题。此外，已经详细讨论了四环素生物降解的特性和比较。另外，

• 强调

• 纯培养菌株和微生物区系对四环素的降解作用显着。

• 总结了生化处理工艺对四环素的降解作用。

• 连续波处理中的先进处理工艺可以消除四环素。

• 提出了四环素生物降解的未来研究方向。