Background: Whether interleukin (IL)-8, IL-10, and IL-18 polymorphisms influence predisposition of inflammatory bowel disease (IBD) remains uncertain. Objectives: The authors conducted a meta-analysis to explore relationships between IL-8, IL-10, or IL-18 polymorphisms and predisposition of IBD by merging the results of eligible literatures. Methods: A thorough literature search in MEDLINE, Embase, Wanfang, VIP, and CNKI was conducted by the authors to identify eligible literatures, and 33 literatures were finally selected for merged analyses. Results: We found that genotypic frequencies of IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872, and IL-10 rs1800896 polymorphisms among cases with IBD and population-based controls differed significantly. Moreover, we found that genotypic frequencies of IL-8 rs4073, IL-10 rs1800871, and IL-18 rs1946518 polymorphisms among cases with IBD and population-based controls of Asian origin differed significantly, whereas genotypic frequency of IL-10 rs1800896 polymorphism among cases with IBD and population-based controls of Caucasian origin also differed significantly. Furthermore, genotypic frequency of IL-18 rs187238 polymorphism among cases with Crohn’s disease (CD) and population-based controls also differed significantly. Conclusions: The present meta-analysis shows that IL-8 rs4073, IL-10 rs1800871, IL-10 rs1800872, IL-10 rs1800896, and IL-18 rs1946518 polymorphisms may influence predisposition of IBD. Furthermore, IL-18 rs187238 polymorphism may influence predisposition of CD, but not predisposition of ulcerative colitis.
Int Arch Allergy Immunol

中文翻译：

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炎性肠病的易感性受IL-8，IL-10和IL-18多态性的影响：荟萃分析。

背景：白介素（ IL）-8， IL-10和IL-18多态性是否会影响炎症性肠病（IBD）的易感性，目前尚不确定。目的：作者进行荟萃分析，通过合并合格文献的结果，探讨IL-8， IL-10或IL-18多态性与IBD易感性之间的关系。方法：作者在MEDLINE，Embase，Wanfang，VIP和CNKI中进行了彻底的文献检索，以鉴定符合条件的文献，最后选择了33篇文献进行合并分析。结果：我们发现在患有IBD的病例和基于人群的对照中，IL-8 rs4073，IL-10 rs1800871，IL-10 rs1800872和IL-10 rs1800896多态性存在显着差异。此外，我们发现在患有IBD的病例和亚洲人群中以人群为基础的对照中，IL-8 rs4073，IL-10 rs1800871和IL-18 rs1946518多态性的基因型频率存在显着差异，而IL-10 rs1800896多态性的基因型频率在病例之间与IBD和以人群为基础的高加索人控制也有显着差异。此外，IL-18的基因型频率克罗恩病（CD）病例与基于人群的对照之间的rs187238多态性也存在显着差异。结论：本荟萃分析显示，IL-8 rs4073，IL-10 rs1800871，IL-10 rs1800872，IL-10 rs1800896和IL-18 rs1946518多态性可能会影响IBD的易感性。此外，IL-18 rs187238的多态性可能会影响CD的易感性，但不会影响溃疡性结肠炎的易感性。
Int Arch过敏免疫