According to reports published, the aberrant expression of microRNAs (miRNAs), a class of 19–25 nucleotide-long small non-coding RNAs, is responsible for human cancers, including nasopharyngeal cancer (NPC). The dysregulation of miRNAs that act either as a tumor suppressor or oncogene, leading to a wide range of NPC pathogenesis pathways, includes the proliferation, invasion, migration as well as the metastasis of NPC cells. This article reviews and highlights recent advances in the studies of miRNAs in NPC, with a specific demonstration of the functions of miRNA, especially circulating miRNAs, in the pathway of NPC pathogenesis. Additionally, the possible use of miRNAs as early screening and prognostic biomarkers and for therapeutic molecular monitoring has been extensively studied.

中文翻译：

---

MicroRNAs：鼻咽癌的早期筛选，预后和治疗性分子监测的生物发生，功能和潜在的生物标志物。

根据已发表的报道，microRNA（miRNA）（一种19-25个核苷酸长的小非编码RNA）的异常表达是导致人类癌症（包括鼻咽癌（NPC））的原因。充当肿瘤抑制因子或致癌基因的miRNA失调，导致广泛的NPC发病途径，包括NPC细胞的增殖，侵袭，迁移以及转移。本文回顾并重点介绍了NPC中miRNA研究的最新进展，并特别展示了miRNA（尤其是循环miRNA）在NPC发病机理中的功能。此外，miRNA作为早期筛选和预后生物标记物以及用于治疗性分子监测的可能用途已得到广泛研究。