Single natural vegetable oils may have some drawbacks in terms of structure and function. Enzymatic interesterification can greatly improve the quality of natural vegetable oils. In this study, soybean oil (SO) and coconut oil (CO) are combined to synthesize structured lipids (SLs) using Lipozyme RM IM as a catalyst to modify the structure of coconut oil, which can make coconut oil have better physicochemical properties. A total of 55.73% structured lipids of total triacylglycerols are synthesized under the optimum reaction conditions. The main fatty acids of SL‐SOCO are linoleic (C18:2, 37.11%), oleic (C18:1, 21.73%), and lauric (C12:0, 14.05%). The most abundant TAG species in SL‐SOCO are (14:0‐18:1‐18:3), (12:0‐14:0‐18:3), and (14:0‐14:0‐18:3) with the relative content of 10.56%, 7.13%, and 5.52%, respectively. Compared to the crystallization curves of SOCO, SL‐SOCO showed a delayed crystallization and a decreased enthalpy. Moreover, the curcumin nanocarrier prepared by SL‐SOCO as the oil phase has good stability, encapsulation efficiency (91.12%), and improved bioavailability (54.02%). To conclude, SL‐SOCO with monounsaturated fatty acid, polyunsaturated fatty acids, and medium‐chain fatty acids has good structural composition and SL‐SOCO nanoparticles have excellent applications in drug delivery system.

中文翻译：

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基于大豆油和椰子油的结构脂质的合成，纯化，表征及其在姜黄素负载型纳米乳液中的应用

单一天然植物油可能在结构和功能方面有一些缺点。酶促酯交换可以大大提高天然植物油的质量。在这项研究中，豆油（SO）和椰子油（CO）结合使用Lipozyme RM IM作为催化剂来合成结构化脂质（SLs），以改性椰子油的结构，这可以使椰子油具有更好的理化特性。在最佳反应条件下，合成了总三酰基甘油中总共55.73％的结构化脂质。SL‐SOCO的主要脂肪酸为亚油酸（C18：2，37.11％），油酸（C18：1，21.73％）和月桂酸（C12：0，14.05％）。SL‐SOCO中最丰富的TAG种类是（14：0‐18：1‐18：3），（12：0‐14：0‐18：3）和（14：0‐14：0‐18： 3）的相对含量分别为10.56％，7.13％和5.52％。与SOCO的结晶曲线相比，SL‐SOCO结晶延迟，焓降低。此外，SL‐SOCO制备的姜黄素纳米载体为油相，具有良好的稳定性，包封效率（91.12％）和更高的生物利用度（54.02％）。总之，具有单不饱和脂肪酸，多不饱和脂肪酸和中链脂肪酸的SL‐SOCO具有良好的结构组成，SL‐SOCO纳米颗粒在药物输送系统中具有出色的应用。